Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/2647
Title: Hemodiyaliz hastalarında GBV-C/HGV prevalansının araştırılması
Other Titles: Prevalence ofGBV-C/HGV in haemodialysis patients
Authors: Hancı Yılmaz, Sevgi
Advisors: Nural Cevahir
Keywords: GBV-C/HGV
Hemodiyaliz
Kan donörü
RT-PCR
GBV-C/HGV
Haemodialysis
Blood donor
RT-PCR
Abstract: Bu çalısmada bölgemizde, hemodiyaliz hastaları ile kan donörlerinde GBVC/ HGV prevalansı, muhtemel geçis yolları ve klinik etkisi arastırılmıstır. Hemodiyaliz uygulanan 100 hasta ve 100 kan donörü çalısma kapsamına alındı. GBV-C/HGV RNA varlıgı RT-PCR yöntemi ile, GBV-C/HGV Anti E2 antikor varlıgı EIA ile belirlendi. Serum ALT ve GGT düzeyleri, HbsAg, anti-HCV, anti-HIV antikorları ve hemodiyalize girme süreleri belirlendi ve kaydedildi. Hemodiyaliz hastalarının 14 (%14)'ünde ve kan donörlerinin 2 (%2)'sinde GBVC/ HGV RNA pozitif saptandı. Hemodiyaliz grubundaki oranlar, kan donörleri grubundan anlamlı derecede yüksekti (p<0.05). GBV-C/HGV Anti E2 antikorlar hemodiyaliz hastalarının 1 (%1)'inde ve kan donörlerinin 3 (%3)'ünde belirlendi. GBVC/ HGV Anti E2 oranlarında gruplar arasında farklılık yoktu. GBV-C/ HGV prevalansı hemodiyaliz hastalarında 14 (%14) ve kan donörlerinde 5 (%5) olarak belirlendi. Hemodiyaliz grubundaki oranlar, kan donörlerinden anlamlı derecede yüksekti (p<0.05). Hemodiyaliz hastaları ve kan donörlerinde GBV-C/HGV ile HBV, HCV ve HIV arasında anlamlı iliski yoktu. GBV-C/HGV pozitif ve negatif hemodiyaliz hastaları arasında hemodiyaliz süresi, serum ALT ve GGT düzeyleri, yas ve cinsiyet açısından anlamlı farklılık yoktu. Sonuç olarak parenteral bulas açısından riskli bir grup olan hemodiyaliz hastalarında GBV-C/HGV viremi riskinin arttıgı kanaatine vardık. Anahtar kelimeler: GBV-C/HGV, hemodiyaliz, kan donörü, RT-PCR
In this study, we aimed that the prevalence of GBV-C/HGV and their potential transmission ways and clinical effects in haemodialysis patients and blood donors in our area. Total of 100 patients on maintenance haemodialysis and 100 blood donors were enrolled this study. The presence of GBV-C/HGV RNA was detected by means of RTPCR and the presence of GBV-C/HGV Anti E2 antibodies was detected by means of EIA. The test results for ALT, GGT, hepatitis B surface antigen (HBsAg), antibodies to HCV, antibodies to HIV and duration of hemodialysis that were measured and recorded. GBV-C/HGV RNA was detected in 14 of 100 haemodialysis patients (%14) and in 2 of 100 blood donors (%2). The rates in haemodialysis groups were significantly higher than that of blood donors (p<0.05). GBV-C/HGV Anti E2 antibodies was detected in 1 of 100 haemodialysis patients (%1) and in 3 of 100 blood donors (%3). There was no singnificantly difference in the GBV-C/HGV Anti E2 antibodies rates betwen the groups. GBV-C/HGV prevalance was appeared in 14 of 100 haemodialysis patients (%14) and in 5 of 100 blood donors (%5). The rates in haemodialysis groups were significantly higher than that of blood donors group (p<0.05). There were no correlation in haemodialysis patients and in blood donors between GBV-C/HGV and HBV, HCV, HIV. There were no significant difference in duration of haemodialysis, serum levels of ALT and GGT, age and sex between GBV-C/HGV positive and GBVC/ HGV negative haemodialysis patients. In conclusion, the risk of GBV-C/HGV viraemia increased in haemodialysis patients that are considered to be at risk of blood borne infections. Key words: GBV-C/HGV, haemodialysis, blood donor, RT-PCR
URI: https://hdl.handle.net/11499/2647
Appears in Collections:Tıp Fakültesi Tez Koleskiyonu

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