Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/30271
Title: Development of cardiac troponin-I biosensor based on boron nitride quantum dots including molecularly imprinted polymer
Authors: Yola, M.L.
Atar, Necip
Keywords: Boron nitride quantum dots
Cardiac Troponin-I
Molecular imprinted biosensor
Plasma
Biochemistry
Biosensors
Body fluids
Boron nitride
Cyclic voltammetry
Diagnosis
Drug products
Electrochemical impedance spectroscopy
Glass membrane electrodes
Heart
III-V semiconductors
Mammals
Nanocrystals
Nitrides
Plasmas
Reusability
Scanning electron microscopy
Transmission electron microscopy
Acute myocardial infarction
Biochemical markers
Bovine serum albumins
Cardiac troponin I
Characterization methods
Glassy carbon electrodes
Molecular imprinted biosensors
Molecularly Imprinted Polymer
Semiconductor quantum dots
boron nitride quantum dot
bovine serum albumin
molecularly imprinted polymer
myoglobin
pyrrole
quantum dot
troponin I
troponin T
unclassified drug
boron derivative
boron nitride
carbon
polymer
Article
controlled study
glassy carbon electrode
human
impedance spectroscopy
limit of detection
measurement repeatability
protein blood level
reproducibility
scanning electron microscopy
transmission electron microscopy
X ray diffraction
chemistry
genetic procedures
isolation and purification
molecular imprinting
Biosensing Techniques
Boron Compounds
Carbon
Dielectric Spectroscopy
Humans
Limit of Detection
Molecular Imprinting
Myoglobin
Polymers
Quantum Dots
Serum Albumin, Bovine
Troponin I
Troponin T
Publisher: Elsevier Ltd
Abstract: The cardiac Troponin-I (cTnI) is one of the subunits of cardiac troponin complexes and a pivotal biochemical marker of acute myocardial infarction (AMI). Due to its myocardial specificity, cTnI is widely used for the diagnosis of AMI diseases. In this study, a novel imprinted biosensor approach based on boron nitride quantum dots (BNQDs) was presented for cTnI detection in plasma samples. Various characterization methods such as scanning electron microscope (SEM), transmission electron microscope (TEM), x-ray diffraction (XRD), cyclic voltammetry (CV) and electrochemical impedance spectroscopy (EIS) were used for all characterizations of nanomaterials. After the characterization analysis, cTnI imprinted electrode was developed in the presence of 100.0 mM pyrrole containing 25.0 mM cTnI. After that, the analytical studies of cTnI in plasma samples were performed by using cTnI imprinted biosensor. The results of the study have revealed that 0.01–5.00 ng mL -1 and 0.0005 ng mL -1 were found as the linearity range and the detection limit (LOD). Moreover, the selectivity of cTnI imprinted glassy carbon electrode (GCE) was investigated for plasma sample analysis in the presence of other nonspecific and specific proteins including cardiac myoglobin (MYG), bovine serum albumin (BSA) and cardiac troponin T (cTnT), respectively. Furthermore, the prepared biosensor was examined in terms of stability, repeatability, reproducibility and reusability. Finally, the imprinted biosensor was applied to the plasma samples having high recovery. © 2018 Elsevier B.V.
URI: https://hdl.handle.net/11499/30271
https://doi.org/10.1016/j.bios.2018.11.016
ISSN: 0956-5663
Appears in Collections:Mühendislik Fakültesi Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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