Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/36873
Title: | Predictors of Human papillomavirus (HPV) persistence after treatment of high grade cervical lesions; does cervical cytology have any prognostic value in primary HPV screening? | Authors: | Kılıç, Derya Güler, Tolga Atigan, A. Avşaroğlu, Elif Karakaya, Yeliz Arman Kaleli, İlknur Kaleli, Mehmet Babür |
Keywords: | Cervical intraepithelial neoplasia Conization Human papillomavirus Persistence adult age aged Article cancer grading cancer patient cancer prognosis cancer surgery cohort analysis colposcopy disease association electrosurgery female follow up human Human papillomavirus type 16 Human papillomavirus type 18 Human papillomavirus type 31 Human papillomavirus type 33 Human papillomavirus type 35 Human papillomavirus type 39 Human papillomavirus type 45 Human papillomavirus type 51 Human papillomavirus type 52 Human papillomavirus type 56 Human papillomavirus type 58 Human papillomavirus type 59 Human papillomavirus type 66 Human papillomavirus type 68 independent variable loop electrosurgical excision procedure major clinical study mass screening nonhuman Papanicolaou test papillomavirus infection patient referral persistent virus infection predictor variable premenopause priority journal retrospective study risk factor university hospital uterine cervix carcinoma in situ uterine cervix conization uterine cervix cytology viral clearance Wart virus |
Publisher: | W.B. Saunders | Abstract: | Objective: This study aimed to determine the factors associated with Human Papillomavirus (HPV) persistence in women undergoing cervical excision for pre-invasive lesions, after they have been referred from a primary HPV screening program. Methods: A retrospective study design involving patients who were treated at a Cervical Disease Screening and Treatment Unit, in a university hospital setting. After initial treatment, cervical HPV infection status was analyzed at the sixth month, first year and then subsequently after the second year. Results: Totally, 395 patients who were diagnosed with pre-invasive cervical lesions and who subsequently undergone cervical excision were identified. In the first-year visit after cervical excision, HPV 18 was cleared in almost all (95.8%) cases, followed by HPV 16 (69.9%) and other hrHPV types (65.6%). Available data documented that 88.6% of women reached clearance after the two-year follow-up. Univariate analysis revealed a significantly higher proportion of HPV clearance among women who were younger (p = 0.019), premenopausal (p = 0.002), and who had been found to have a negative cytology result on their initial Pap test (p = 0.018). However, only cervical cytology result remained as the independent predictor of HPV persistence on a multivariate logistic regression (OR 0.43; 95% CI 0.21–0.87; p = 0.019). Conclusions: A low risk of HPV persistence was found among every HPV genotype in women undergoing cervical excision for pre-invasive cervical lesions. Initial cervical cytology result was the only independent predictor of HPV clearance during surveillance, which indicates the prognostic value of Pap test in primary HPV screening. © 2020 Elsevier Inc. | URI: | https://hdl.handle.net/11499/36873 https://doi.org/10.1016/j.anndiagpath.2020.151626 |
ISSN: | 1092-9134 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Show full item record
CORE Recommender
SCOPUSTM
Citations
11
checked on Dec 14, 2024
WEB OF SCIENCETM
Citations
8
checked on Dec 19, 2024
Page view(s)
54
checked on Aug 24, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.