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https://hdl.handle.net/11499/36890
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Hepokur, C. | - |
dc.contributor.author | Misir, S. | - |
dc.contributor.author | Tunc, T. | - |
dc.contributor.author | Tutar, U. | - |
dc.contributor.author | Çiçek, Mehmet | - |
dc.contributor.author | Hepokur, Ali İhsan | - |
dc.date.accessioned | 2021-02-02T09:23:12Z | - |
dc.date.available | 2021-02-02T09:23:12Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 0250-4685 | - |
dc.identifier.uri | https://hdl.handle.net/11499/36890 | - |
dc.identifier.uri | https://doi.org/10.1515/tjb-2019-0470 | - |
dc.description.abstract | Objectives: In this study, we aimed to detect the chemical compounds of Thymbra capitata ethanolic extract (TC-EtOH) as well as to evaluated its antimicrobial, antioxidant, cytotoxic activities, and in vivo wound healing effects. Methods: The chemical composition of TC-EtOH was analyzed by Gas chromatography-mass spectrometry (GC-MS). Antioxidant and antimicrobial properties were determined with 2,2-diphenyl-1-picrylhydrazyl (DPPH), disc diffusion test and broth micro-dilution (minimal inhibitory concentration [MIC]) methods, respectively. Cytotoxic activity was tested on MG63 (human osteosarcoma) and MCF-7 (human breast carcinoma) cells by 2,3-bis-(2-methoxy-4-nitro-5-sulfophenyl)-2H-tetrazolium- 5-carboxanilide (XTT) assay. Tumor necrosis factor alpha (TNF-?) protein levels were determined by ELISA. Results: The major components of TC-EtOH were tetratria contane (14.92%), camphor (12.50%), and terpineol (10.77%). TC-EtOH showed powerful antimicrobial activity in C. Tropicalis (0.03 mg/mL). The IC50 values of the TC-EtOH of the DPPH were determined 21.5 µg/mL. The IC50 values were calculated 37.28 and 44.40 µg/mL on the MG63 and MCF-7 cell lines, respectively. It was observed that the wounds treated with TC-EtOH showed a faster healing. Conclusions: According to results, T. capitata species are thought to be natural antioxidants and a novel pharmaceutical compound for the pharmaceutical industry. © 2020 De Gruyter. All rights reserved. | en_US |
dc.language.iso | en | en_US |
dc.publisher | De Gruyter Open Ltd | en_US |
dc.relation.ispartof | Turkish Journal of Biochemistry | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Antimicrobial | en_US |
dc.subject | Antioxidant | en_US |
dc.subject | Cytotoxic activity | en_US |
dc.subject | Thymbra capitata | en_US |
dc.subject | Wound healing | en_US |
dc.title | In vitro antimicrobial, antioxidant, cytotoxic activities, and wound healing potential of Thymbra capitata ethanolic extract | en_US |
dc.title.alternative | Thymbra capitata etanolik ekstraktının in vitro antimikrobiyal, antioksidan, sitotoksik aktiviteleri ve yara iyileşme potansiyeli | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 45 | en_US |
dc.identifier.issue | 6 | en_US |
dc.identifier.startpage | 843 | - |
dc.identifier.startpage | 843 | en_US |
dc.identifier.endpage | 849 | en_US |
dc.authorid | 0000-0003-4058-3717 | - |
dc.identifier.doi | 10.1515/tjb-2019-0470 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopus | 2-s2.0-85098958602 | en_US |
dc.identifier.trdizinid | 455043 | en_US |
dc.identifier.wos | WOS:000603517600025 | en_US |
dc.identifier.scopusquality | Q4 | - |
dc.owner | Pamukkale University | - |
item.languageiso639-1 | en | - |
item.openairetype | Article | - |
item.grantfulltext | open | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
crisitem.author.dept | 17.05. Molecular Biology and Genetics | - |
Appears in Collections: | Fen-Edebiyat Fakültesi Koleksiyonu Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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ea15a5b3-c487-41d2-8989-ce39cbc37e29.pdf | 1.8 MB | Adobe PDF | View/Open |
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