Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/37016
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dc.contributor.authorLektemür Alpan, Aysan-
dc.contributor.authorKızıldağ, Alper-
dc.contributor.authorÖzdede, Melih-
dc.contributor.authorKarakan, N.C.-
dc.contributor.authorÖzmen, Ö.-
dc.date.accessioned2021-02-02T09:23:37Z
dc.date.available2021-02-02T09:23:37Z
dc.date.issued2020-
dc.identifier.issn0003-9969-
dc.identifier.urihttps://hdl.handle.net/11499/37016-
dc.identifier.urihttps://doi.org/10.1016/j.archoralbio.2020.104823-
dc.description.abstractObjective: This study aimed to evaluate the effect of taxifolin, a powerful antioxidant, on the progression of periodontitis by immunohistochemical and cone-beam computed tomography (CBCT) examination. Design: This study was performed with 32 rats in four experimental groups: a non-ligated group (Control, n = 8), periodontitis group (Perio, n = 8), periodontitis with 1 mg/kg/day taxifolin group (Taxi-1, n = 8), and periodontitis with 10 mg/kg/day taxifolin group (Taxi-10, n = 8). A ligature-induced experimental periodontitis design was used. All rats were sacrificed at 30 days. Alveolar bone loss was determined by CBCT. Hematoxylin–eosin stained slides were examined. The expression levels of bone morphogenetic protein 2 (BMP-2), osteocalcin (OCN), alkaline phosphatase (ALP), collagen type I (Col 1), Bcl-2, Bax, and receptor activator of NF-?B ligand (RANKL) were determined immunohistochemically. Results: Both doses of taxifolin showed a decrease in alveolar bone loss. The inflammatory reaction was higher in the Perio group and lower in the taxifolin groups. BMP-2, OCN, ALP, and Col 1 expression were dose-dependently elevated in the taxifolin groups. RANKL immunoexpression decreased with both doses of taxifolin. Bcl-2 expression increased and Bax expression decreased in the taxifolin groups. Conclusion: Taxifolin successfully reduced apoptosis and improved bone formation in alveolar bone in this experimental periodontitis model. © 2020 Elsevier Ltden_US
dc.language.isoenen_US
dc.publisherElsevier Ltden_US
dc.relation.ispartofArchives of Oral Biologyen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectAntioxidanten_US
dc.subjectApoptosisen_US
dc.subjectBone formationen_US
dc.subjectCone-beam computed tomographyen_US
dc.subjectDihydroquercetinen_US
dc.subjectExperimental periodontitisen_US
dc.subjectImmunohistochemistryen_US
dc.subjectRANKLen_US
dc.subjectRaten_US
dc.subjectReactive oxygen speciesen_US
dc.subjectTaxifolinen_US
dc.subjectosteocalcinen_US
dc.subjectosteoclast differentiation factoren_US
dc.subjectquercetinen_US
dc.subjecttaxifolinen_US
dc.subjectalveolar bone lossen_US
dc.subjectanimalen_US
dc.subjectapoptosisen_US
dc.subjectdiagnostic imagingen_US
dc.subjectmetabolismen_US
dc.subjectperiodontitisen_US
dc.subjectraten_US
dc.subjectAlveolar Bone Lossen_US
dc.subjectAnimalsen_US
dc.subjectOsteocalcinen_US
dc.subjectPeriodontitisen_US
dc.subjectQuercetinen_US
dc.subjectRANK Liganden_US
dc.subjectRatsen_US
dc.titleThe effects of taxifolin on alveolar bone in experimental periodontitis in ratsen_US
dc.typeArticleen_US
dc.identifier.volume117en_US
dc.authorid0000-0002-5939-4783-
dc.authorid0000-0002-1630-3140-
dc.authorid0000-0002-8783-802X-
dc.identifier.doi10.1016/j.archoralbio.2020.104823-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid32593876en_US
dc.identifier.scopus2-s2.0-85086770827en_US
dc.identifier.wosWOS:000558537200029en_US
dc.identifier.scopusqualityQ1-
dc.ownerPamukkale University-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextnone-
crisitem.author.dept06.01. Clinical Sciences-
crisitem.author.dept06.01. Clinical Sciences-
crisitem.author.dept06.01. Clinical Sciences-
Appears in Collections:Diş Hekimliği Fakültesi Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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