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https://hdl.handle.net/11499/38020
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Semiz, Aslı | - |
dc.contributor.author | Acar, Özden Özgün | - |
dc.contributor.author | Çetin, Hülya | - |
dc.contributor.author | Semiz, Gürkan | - |
dc.contributor.author | Şen, Alaattin | - |
dc.date.accessioned | 2021-02-02T12:39:52Z | - |
dc.date.available | 2021-02-02T12:39:52Z | - |
dc.date.issued | 2020 | - |
dc.identifier.issn | 2450-131X | - |
dc.identifier.uri | https://hdl.handle.net/11499/38020 | - |
dc.identifier.uri | https://doi.org/10.2478/jtim-2020-0027 | - |
dc.description.abstract | Background and Objective: This study was aimed to elucidate the molecular mechanism of Momordica charantia (MCh), along with a standard drug prednisolone, in a rat model of colitis induced by trinitrobenzene sulfonic acid (TNBS). Methods: After the induction of the experimental colitis, the animals were treated with MCh (4 g/kg/day) for 14 consecutive days by intragastric gavage. The colonic tissue expression levels of C-C motif chemokine ligand 17 (CCL-17), interleukin (IL)-1 beta, IL-6, IL-23, interferon-gamma (IFN-gamma), nuclear factor kappa B (NFkB), and tumor necrosis factor-alpha (TNF-alpha), were determined at both mRNA and protein levels to estimate the effect of MCh. Besides, colonic specimens were analyzed histopathologically after staining with hematoxylin and eosin. Results: The body weights from TNBS-instigated colitis rats were found to be significantly lower than untreated animals. Also, the IFN-gamma, IL-1 beta, IL-6, Il-23, TNF-alpha, CCL-17, and NF-kB mRNA and protein levels were increased significantly from 1.86-4.91-fold and 1.46-5.50-fold, respectively, in the TNBS-instigated colitis group as compared to the control. Both the MCh and prednisolone treatment significantly reduced the bodyweight loss. It also restored the induced colonic tissue levels of IL-1 beta, IL-6, IFN-gamma, and TNF-alpha to normal levels seen in untreated animals. These results were also supported with the histochemical staining of the colonic tissues from both control and treated animals. Conclusion: The presented data strongly suggests that MCh has the anti-inflammatory effect that might be modulated through vitamin D metabolism. It is the right candidate for the treatment of UC as an alternative and complementary therapeutics. | en_US |
dc.language.iso | en | en_US |
dc.publisher | SCIENDO | en_US |
dc.relation.ispartof | JOURNAL OF TRANSLATIONAL INTERNAL MEDICINE | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Momordica charantia; ulcerative colitis; inflammatory bowel disease; | en_US |
dc.subject | anti-inflammatory; inflammatory cytokines; vitamin D; CYP27B1; | en_US |
dc.subject | trinitrobenzenesulfonic acid; immunohistochemistry; alternative and | en_US |
dc.subject | complementary therapeutics | en_US |
dc.title | Suppression of inflammatory cytokines expression with bitter melon (Momordica charantia) in TNBS-instigated ulcerative colitis | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 8 | en_US |
dc.identifier.issue | 3 | en_US |
dc.identifier.startpage | 177 | - |
dc.identifier.startpage | 177 | en_US |
dc.identifier.endpage | 187 | en_US |
dc.authorid | 0000-0001-8952-5070 | - |
dc.authorid | 0000-0002-2910-6349 | - |
dc.authorid | 0000-0001-8731-0631 | - |
dc.authorid | 0000-0003-0276-8542 | - |
dc.identifier.doi | 10.2478/jtim-2020-0027 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 33062594 | en_US |
dc.identifier.scopus | 2-s2.0-85127704378 | en_US |
dc.identifier.wos | WOS:000576292000009 | en_US |
dc.identifier.scopusquality | - | - |
dc.owner | Pamukkale University | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | Article | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
crisitem.author.dept | 20.03. Biomedical Engineering | - |
crisitem.author.dept | 29. Denizli Health Services Vocational School of Higher Education | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
crisitem.author.dept | 17.02. Biology | - |
crisitem.author.dept | 17.02. Biology | - |
Appears in Collections: | Fen-Edebiyat Fakültesi Koleksiyonu PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Teknoloji Fakültesi Koleksiyonu Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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