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https://hdl.handle.net/11499/4288
Title: | Nilvadipine prevents the impairment of spatial memory induced by cerebral ischemia combined with ß-amyloid in rats | Authors: | Iwasaki, K. Egashira, N. Takagaki, Y. Yoshimitsu, Y. Hatip-Al-Khatib, İzzettin Mishima, K. Fujiwara, M. |
Keywords: | ß-amyloid Alzheimer's disease Apoptosis Ischemia Nilvadipine Spatial memory amlodipine amyloid beta protein nilvadipine animal experiment animal model article brain ischemia drug mechanism hippocampus male memory disorder nerve cell necrosis nonhuman rat spatial memory Amyloid beta-Protein Animals Brain Ischemia Calcium Channel Blockers Male Maze Learning Memory Disorders Neurons Nifedipine Rats Rats, Wistar Space Perception |
Abstract: | In the present study, we examined the effects of nilvadipine and amlodipine, both dihydropyridine-derivative calcium antagonists, on the impairment of spatial memory induced by a combination of ischemia and ß-amyloid (Aß). Nilvadipine (3.2 mg/kg, i.p.) significantly prevented the impairment of spatial memory and neuronal apoptosis in this model. By contrast, amlodipine had no effect on this impairment of spatial memory. These findings suggest that nilvadipine may prevent impairment of spatial memory by inhibiting neuronal apoptosis; this drug might therefore be useful for the prevention of the progression to dementia in Alzheimer's disease (AD). © 2007 Pharmaceutical Society of Japan. | URI: | https://hdl.handle.net/11499/4288 https://doi.org/10.1248/bpb.30.698 |
ISSN: | 0918-6158 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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