Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4288
Title: Nilvadipine prevents the impairment of spatial memory induced by cerebral ischemia combined with ß-amyloid in rats
Authors: Iwasaki, K.
Egashira, N.
Takagaki, Y.
Yoshimitsu, Y.
Hatip-Al-Khatib, İzzettin
Mishima, K.
Fujiwara, M.
Keywords: ß-amyloid
Alzheimer's disease
Apoptosis
Ischemia
Nilvadipine
Spatial memory
amlodipine
amyloid beta protein
nilvadipine
animal experiment
animal model
article
brain ischemia
drug mechanism
hippocampus
male
memory disorder
nerve cell necrosis
nonhuman
rat
spatial memory
Amyloid beta-Protein
Animals
Brain Ischemia
Calcium Channel Blockers
Male
Maze Learning
Memory Disorders
Neurons
Nifedipine
Rats
Rats, Wistar
Space Perception
Abstract: In the present study, we examined the effects of nilvadipine and amlodipine, both dihydropyridine-derivative calcium antagonists, on the impairment of spatial memory induced by a combination of ischemia and ß-amyloid (Aß). Nilvadipine (3.2 mg/kg, i.p.) significantly prevented the impairment of spatial memory and neuronal apoptosis in this model. By contrast, amlodipine had no effect on this impairment of spatial memory. These findings suggest that nilvadipine may prevent impairment of spatial memory by inhibiting neuronal apoptosis; this drug might therefore be useful for the prevention of the progression to dementia in Alzheimer's disease (AD). © 2007 Pharmaceutical Society of Japan.
URI: https://hdl.handle.net/11499/4288
https://doi.org/10.1248/bpb.30.698
ISSN: 0918-6158
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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