Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4300
Full metadata record
DC FieldValueLanguage
dc.contributor.authorYildirim, Başak Nazan.-
dc.contributor.authorAbban, Gülçin.-
dc.contributor.authorRota, Simin.-
dc.contributor.authorJetten, A.-
dc.date.accessioned2019-08-16T11:33:16Z-
dc.date.available2019-08-16T11:33:16Z-
dc.date.issued2007-
dc.identifier.issn1309-0399-
dc.identifier.urihttps://hdl.handle.net/11499/4300-
dc.description.abstractObjective: In growth and differentation of keratinizing stratified squamous epithelium, 1.25-dihydroxyvitamin D3 has an important role. Cornifin ? as a marker of vaginal epithelial differentiation distribution in vagina epithelium has not been studied. We examined distribution of VDR and cornifin ? in vagina epithelium in ovariectomized and treated vitamin D rats. Materials and Methods: Bilateral ovariectomies were performed in 20 mature non-pregnant Wistar female rats. All the animals were divided into 2 groups; control group I untreated and group II i.m. 0.025 µg 1.25-dihydroxyvitamin D3 injected for three days of a week for 2 weeks. In 15 days after the last injection, vaginas were removed and processed for immunohistochemistry. Results: Recorded epithelial differentiation, 1.25-dihydroxyvitamin D 3 receptor and cornifin ? expression in vaginal epithelium of control and vitamin D3 treated rats. In treated animals, vaginal epithelium changed into highly-stratified keratinizing layers. Cornifin ? and 1.25-dihydroxyvitamin D3 receptor as a marker of squamous differentiation is present in ovariectomized rats treated with 1.25-dihydroxyvitamin D3. In contrast, cornifin ? and 1.25-dihydroxyvitamin D3 receptor were absent in all layers of vaginal epithelium in control group. Discussion: The results indicate that 1.25-dihydroxyvitamin D3 induced proliferation of vaginal epithelium which was consistent with the cornifin ? expression. We demonstrated for the first time that 1.25-dihydroxyvitamin D3 up-regulated 1.25-dihydroxyvitamin D3 receptor expression in vaginal epithelium.en_US
dc.language.isoenen_US
dc.relation.ispartofJournal of the Turkish German Gynecology Associationen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCornifin ?en_US
dc.subjectImmunohistochemistryen_US
dc.subjectVaginaen_US
dc.subjectVDRen_US
dc.subjectVitamin Den_US
dc.subjectcolecalciferolen_US
dc.subjectcornifinen_US
dc.subjectcornifin alphaen_US
dc.subjectunclassified drugen_US
dc.subjectvitamin D receptoren_US
dc.subjectanimal cellen_US
dc.subjectanimal experimenten_US
dc.subjectarticleen_US
dc.subjectcell differentiationen_US
dc.subjectcell growthen_US
dc.subjectcell proliferationen_US
dc.subjectcontrolled studyen_US
dc.subjectdrug effecten_US
dc.subjectfemaleen_US
dc.subjecthistopathologyen_US
dc.subjectimmunohistochemistryen_US
dc.subjectnonhumanen_US
dc.subjectraten_US
dc.subjectvagina epitheliumen_US
dc.titleImmunohistochemical detection and distribution of cornifin ? and vitamin D receptor expression in vaginal epithelium treated with vitamin D 3en_US
dc.title.alternativeVitamin D3 verilen sıçanların vajen epitelinde kornifin alfa ve vitamin D reseptör ekspresyonun immünohistokimyasal olarak belirlenmesi-
dc.typeArticleen_US
dc.identifier.volume8en_US
dc.identifier.issue1en_US
dc.identifier.startpage33en_US
dc.identifier.endpage37en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopus2-s2.0-34247513835en_US
dc.identifier.wosWOS:000420580900005en_US
dc.identifier.scopusqualityQ4-
dc.ownerPamukkale University-
item.languageiso639-1en-
item.fulltextNo Fulltext-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextnone-
crisitem.author.dept14.01. Surgical Medicine-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.03. Basic Medical Sciences-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
Show simple item record



CORE Recommender

SCOPUSTM   
Citations

1
checked on Oct 13, 2024

Page view(s)

46
checked on Aug 24, 2024

Google ScholarTM

Check





Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.