Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4300
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dc.contributor.authorYildirim, Başak Nazan.-
dc.contributor.authorAbban, Gülçin.-
dc.contributor.authorRota, Simin.-
dc.contributor.authorJetten, A.-
dc.date.accessioned2019-08-16T11:33:16Z-
dc.date.available2019-08-16T11:33:16Z-
dc.date.issued2007-
dc.identifier.issn1309-0399-
dc.identifier.urihttps://hdl.handle.net/11499/4300-
dc.description.abstractObjective: In growth and differentation of keratinizing stratified squamous epithelium, 1.25-dihydroxyvitamin D3 has an important role. Cornifin ? as a marker of vaginal epithelial differentiation distribution in vagina epithelium has not been studied. We examined distribution of VDR and cornifin ? in vagina epithelium in ovariectomized and treated vitamin D rats. Materials and Methods: Bilateral ovariectomies were performed in 20 mature non-pregnant Wistar female rats. All the animals were divided into 2 groups; control group I untreated and group II i.m. 0.025 µg 1.25-dihydroxyvitamin D3 injected for three days of a week for 2 weeks. In 15 days after the last injection, vaginas were removed and processed for immunohistochemistry. Results: Recorded epithelial differentiation, 1.25-dihydroxyvitamin D 3 receptor and cornifin ? expression in vaginal epithelium of control and vitamin D3 treated rats. In treated animals, vaginal epithelium changed into highly-stratified keratinizing layers. Cornifin ? and 1.25-dihydroxyvitamin D3 receptor as a marker of squamous differentiation is present in ovariectomized rats treated with 1.25-dihydroxyvitamin D3. In contrast, cornifin ? and 1.25-dihydroxyvitamin D3 receptor were absent in all layers of vaginal epithelium in control group. Discussion: The results indicate that 1.25-dihydroxyvitamin D3 induced proliferation of vaginal epithelium which was consistent with the cornifin ? expression. We demonstrated for the first time that 1.25-dihydroxyvitamin D3 up-regulated 1.25-dihydroxyvitamin D3 receptor expression in vaginal epithelium.en_US
dc.language.isoenen_US
dc.relation.ispartofJournal of the Turkish German Gynecology Associationen_US
dc.rightsinfo:eu-repo/semantics/closedAccessen_US
dc.subjectCornifin ?en_US
dc.subjectImmunohistochemistryen_US
dc.subjectVaginaen_US
dc.subjectVDRen_US
dc.subjectVitamin Den_US
dc.subjectcolecalciferolen_US
dc.subjectcornifinen_US
dc.subjectcornifin alphaen_US
dc.subjectunclassified drugen_US
dc.subjectvitamin D receptoren_US
dc.subjectanimal cellen_US
dc.subjectanimal experimenten_US
dc.subjectarticleen_US
dc.subjectcell differentiationen_US
dc.subjectcell growthen_US
dc.subjectcell proliferationen_US
dc.subjectcontrolled studyen_US
dc.subjectdrug effecten_US
dc.subjectfemaleen_US
dc.subjecthistopathologyen_US
dc.subjectimmunohistochemistryen_US
dc.subjectnonhumanen_US
dc.subjectraten_US
dc.subjectvagina epitheliumen_US
dc.titleImmunohistochemical detection and distribution of cornifin ? and vitamin D receptor expression in vaginal epithelium treated with vitamin D 3en_US
dc.title.alternativeVitamin D3 verilen sıçanların vajen epitelinde kornifin alfa ve vitamin D reseptör ekspresyonun immünohistokimyasal olarak belirlenmesi-
dc.typeArticleen_US
dc.identifier.volume8en_US
dc.identifier.issue1en_US
dc.identifier.startpage33en_US
dc.identifier.endpage37en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.scopus2-s2.0-34247513835en_US
dc.identifier.wosWOS:000420580900005en_US
dc.identifier.scopusqualityQ4-
dc.ownerPamukkale University-
item.fulltextNo Fulltext-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextnone-
item.openairetypeArticle-
crisitem.author.dept14.01. Surgical Medicine-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.03. Basic Medical Sciences-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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