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https://hdl.handle.net/11499/4300
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DC Field | Value | Language |
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dc.contributor.author | Yildirim, Başak Nazan. | - |
dc.contributor.author | Abban, Gülçin. | - |
dc.contributor.author | Rota, Simin. | - |
dc.contributor.author | Jetten, A. | - |
dc.date.accessioned | 2019-08-16T11:33:16Z | - |
dc.date.available | 2019-08-16T11:33:16Z | - |
dc.date.issued | 2007 | - |
dc.identifier.issn | 1309-0399 | - |
dc.identifier.uri | https://hdl.handle.net/11499/4300 | - |
dc.description.abstract | Objective: In growth and differentation of keratinizing stratified squamous epithelium, 1.25-dihydroxyvitamin D3 has an important role. Cornifin ? as a marker of vaginal epithelial differentiation distribution in vagina epithelium has not been studied. We examined distribution of VDR and cornifin ? in vagina epithelium in ovariectomized and treated vitamin D rats. Materials and Methods: Bilateral ovariectomies were performed in 20 mature non-pregnant Wistar female rats. All the animals were divided into 2 groups; control group I untreated and group II i.m. 0.025 µg 1.25-dihydroxyvitamin D3 injected for three days of a week for 2 weeks. In 15 days after the last injection, vaginas were removed and processed for immunohistochemistry. Results: Recorded epithelial differentiation, 1.25-dihydroxyvitamin D 3 receptor and cornifin ? expression in vaginal epithelium of control and vitamin D3 treated rats. In treated animals, vaginal epithelium changed into highly-stratified keratinizing layers. Cornifin ? and 1.25-dihydroxyvitamin D3 receptor as a marker of squamous differentiation is present in ovariectomized rats treated with 1.25-dihydroxyvitamin D3. In contrast, cornifin ? and 1.25-dihydroxyvitamin D3 receptor were absent in all layers of vaginal epithelium in control group. Discussion: The results indicate that 1.25-dihydroxyvitamin D3 induced proliferation of vaginal epithelium which was consistent with the cornifin ? expression. We demonstrated for the first time that 1.25-dihydroxyvitamin D3 up-regulated 1.25-dihydroxyvitamin D3 receptor expression in vaginal epithelium. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Journal of the Turkish German Gynecology Association | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | Cornifin ? | en_US |
dc.subject | Immunohistochemistry | en_US |
dc.subject | Vagina | en_US |
dc.subject | VDR | en_US |
dc.subject | Vitamin D | en_US |
dc.subject | colecalciferol | en_US |
dc.subject | cornifin | en_US |
dc.subject | cornifin alpha | en_US |
dc.subject | unclassified drug | en_US |
dc.subject | vitamin D receptor | en_US |
dc.subject | animal cell | en_US |
dc.subject | animal experiment | en_US |
dc.subject | article | en_US |
dc.subject | cell differentiation | en_US |
dc.subject | cell growth | en_US |
dc.subject | cell proliferation | en_US |
dc.subject | controlled study | en_US |
dc.subject | drug effect | en_US |
dc.subject | female | en_US |
dc.subject | histopathology | en_US |
dc.subject | immunohistochemistry | en_US |
dc.subject | nonhuman | en_US |
dc.subject | rat | en_US |
dc.subject | vagina epithelium | en_US |
dc.title | Immunohistochemical detection and distribution of cornifin ? and vitamin D receptor expression in vaginal epithelium treated with vitamin D 3 | en_US |
dc.title.alternative | Vitamin D3 verilen sıçanların vajen epitelinde kornifin alfa ve vitamin D reseptör ekspresyonun immünohistokimyasal olarak belirlenmesi | - |
dc.type | Article | en_US |
dc.identifier.volume | 8 | en_US |
dc.identifier.issue | 1 | en_US |
dc.identifier.startpage | 33 | en_US |
dc.identifier.endpage | 37 | en_US |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopus | 2-s2.0-34247513835 | en_US |
dc.identifier.wos | WOS:000420580900005 | en_US |
dc.identifier.scopusquality | Q4 | - |
dc.owner | Pamukkale University | - |
item.languageiso639-1 | en | - |
item.fulltext | No Fulltext | - |
item.openairetype | Article | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.cerifentitytype | Publications | - |
item.grantfulltext | none | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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