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https://hdl.handle.net/11499/4383
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Kaptanoglu, Bünyamin. | - |
dc.contributor.author | Turgut, Günfer. | - |
dc.contributor.author | Emmungil, Gülten. | - |
dc.contributor.author | Turgut, Sabahat. | - |
dc.contributor.author | Demir, Süleyman. | - |
dc.date.accessioned | 2019-08-16T11:33:47Z | |
dc.date.available | 2019-08-16T11:33:47Z | |
dc.date.issued | 2007 | - |
dc.identifier.issn | 0792-6855 | - |
dc.identifier.uri | https://hdl.handle.net/11499/4383 | - |
dc.identifier.uri | https://doi.org/10.1515/JBCPP.2007.18.4.245 | - |
dc.description.abstract | Background. The aim of this research was to investigate the toxic effects of aluminum (Al) on plasma insulin-like growth factor I (IGF-I) levels and on the liver, the main production site of IGF-I. In addition, we analyzed the influence of Al on liver malondialdehyde (MDA) and glutathione (GSH) levels, and how the antioxidant vitamin E (vit E) affects the altered levels of these parameters. Methods. Adult male rats (n = 28) were randomly divided into the following four groups: Al alone, Al + vit E, vit E alone, and untreated control group. The Al group received 1 mg/200 g body weight of aluminum sulfate (AISO4) thrice weekly for two weeks. The Al + vit E group received the same dose of AISO4 plus 100 mg/kg of vit E once daily. The Vit E group received a daily dose of vit E alone. Control animals received physiologic saline daily. Results. Liver GSH levels were decreased in the Al group but recovered with vit E administration. Liver IGF-I levels significantly decreased in the Al group compared with the control. With the use of vit E, the liver IGF-I levels increased, but this increase was not statistically significant. Conclusions. The results of this study show that plasma and liver IGF-I levels decrease with Al use. Also liver GSH levels decreased with Al while this recovered with vit E use together with Al. © 2007, by Walter de Gruyter GmbH & Co. All rights reserved. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | Journal of Basic and Clinical Physiology and Pharmacology | en_US |
dc.rights | info:eu-repo/semantics/closedAccess | en_US |
dc.subject | alpha tocopherol | en_US |
dc.subject | aluminum | en_US |
dc.subject | aluminum sulfate | en_US |
dc.subject | glutathione | en_US |
dc.subject | malonaldehyde | en_US |
dc.subject | sodium chloride | en_US |
dc.subject | somatomedin C | en_US |
dc.subject | animal experiment | en_US |
dc.subject | antioxidant activity | en_US |
dc.subject | article | en_US |
dc.subject | body weight | en_US |
dc.subject | comparative study | en_US |
dc.subject | control group | en_US |
dc.subject | controlled study | en_US |
dc.subject | liver level | en_US |
dc.subject | male | en_US |
dc.subject | monotherapy | en_US |
dc.subject | nonhuman | en_US |
dc.subject | parameter | en_US |
dc.subject | rat | en_US |
dc.subject | statistical significance | en_US |
dc.subject | toxicity | en_US |
dc.subject | vitamin blood level | en_US |
dc.subject | Alum Compounds | en_US |
dc.subject | Animals | en_US |
dc.subject | Antioxidants | en_US |
dc.subject | Glutathione | en_US |
dc.subject | Immunoenzyme Techniques | en_US |
dc.subject | Insulin-Like Growth Factor I | en_US |
dc.subject | Liver | en_US |
dc.subject | Male | en_US |
dc.subject | Malondialdehyde | en_US |
dc.subject | Random Allocation | en_US |
dc.subject | Vitamin E | en_US |
dc.title | Effects of aluminum on insulin-like growth factor i levels and antioxidant status | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 18 | en_US |
dc.identifier.issue | 4 | en_US |
dc.identifier.startpage | 245 | |
dc.identifier.startpage | 245 | en_US |
dc.identifier.endpage | 254 | en_US |
dc.authorid | 0000-0003-4156-4040 | - |
dc.identifier.doi | 10.1515/JBCPP.2007.18.4.245 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.scopus | 2-s2.0-39449098504 | en_US |
dc.identifier.scopusquality | Q2 | - |
dc.owner | Pamukkale University | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.fulltext | No Fulltext | - |
item.grantfulltext | none | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | Article | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu |
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