Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4383
Title: Effects of aluminum on insulin-like growth factor i levels and antioxidant status
Authors: Kaptanoglu, Bünyamin.
Turgut, Günfer.
Emmungil, Gülten.
Turgut, Sabahat.
Demir, Süleyman.
Keywords: alpha tocopherol
aluminum
aluminum sulfate
glutathione
malonaldehyde
sodium chloride
somatomedin C
animal experiment
antioxidant activity
article
body weight
comparative study
control group
controlled study
liver level
male
monotherapy
nonhuman
parameter
rat
statistical significance
toxicity
vitamin blood level
Alum Compounds
Animals
Antioxidants
Glutathione
Immunoenzyme Techniques
Insulin-Like Growth Factor I
Liver
Male
Malondialdehyde
Random Allocation
Vitamin E
Abstract: Background. The aim of this research was to investigate the toxic effects of aluminum (Al) on plasma insulin-like growth factor I (IGF-I) levels and on the liver, the main production site of IGF-I. In addition, we analyzed the influence of Al on liver malondialdehyde (MDA) and glutathione (GSH) levels, and how the antioxidant vitamin E (vit E) affects the altered levels of these parameters. Methods. Adult male rats (n = 28) were randomly divided into the following four groups: Al alone, Al + vit E, vit E alone, and untreated control group. The Al group received 1 mg/200 g body weight of aluminum sulfate (AISO4) thrice weekly for two weeks. The Al + vit E group received the same dose of AISO4 plus 100 mg/kg of vit E once daily. The Vit E group received a daily dose of vit E alone. Control animals received physiologic saline daily. Results. Liver GSH levels were decreased in the Al group but recovered with vit E administration. Liver IGF-I levels significantly decreased in the Al group compared with the control. With the use of vit E, the liver IGF-I levels increased, but this increase was not statistically significant. Conclusions. The results of this study show that plasma and liver IGF-I levels decrease with Al use. Also liver GSH levels decreased with Al while this recovered with vit E use together with Al. © 2007, by Walter de Gruyter GmbH & Co. All rights reserved.
URI: https://hdl.handle.net/11499/4383
https://doi.org/10.1515/JBCPP.2007.18.4.245
ISSN: 0792-6855
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu

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