Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/46052
Title: Pentraxin 3 levels and correlation with disease severity in patients with acute rheumatic fever
Authors: Gurses, Dolunay
Oguz, Merve
Yilmaz, Munevver
Aybek, Hulya
Akpinar, Funda
Keywords: Acute rheumatic fever
child
pentraxin 3
Ptx3
Echocardiography
Diagnosis
Criteria
Tissue
Publisher: Turkish League Against Rheumatism
Abstract: Objectives: This study aims to investigate serum pentraxin 3 (PTX3) levels during acute episode of acute rheumatic fever (ARF) and their relationship with disease severity. Patients and methods: The prospective study was conducted between January 2015 and December 2018 and included 52 ARF patients (22 girls, 30 boys, mean age 10.7 +/- 2.1 years; range, 5 to 16 years) experiencing an acute episode and 22 healthy children (13 girls, 9 boys, mean age 10.3 +/- 3.8 years; range, 5 to 16 years). ARF patients were classified into three groups based on the clinical course: isolated arthritis (n=17), mild carditis (n=19), and moderate/severe carditis (n=16). Blood samples were collected from all patients before treatment and from the healthy children in the control group to measure PTX3 levels. PTX3 was measured using sandwich enzyme-linked immunosorbent assay method. Results: Plasma PTX3 levels were significantly higher in ARF group compared to the control group (4.7 +/- 5.2 and 1.2 +/- 1.7 ng/mL, p<0.001). Subgroup analysis of serum PTX3 levels in ARF patients with isolated arthritis, mild carditis, and moderate/severe carditis (3.2 +/- 3.1 ng/mL, 4.3 +/- 5 ng/mL, and 6.7 +/- 6.6 ng/mL, respectively) showed that serum PTX3 was significantly higher in the moderate/severe carditis group compared to the other groups (p<0.05). Analysis of echocardiographic data showed that serum PTX3 was positively correlated with left ventricular end-diastolic diameter, left atrial diameters, and mitral A velocity and negatively correlated with E/A ratio (p<0.05; r=0.231, 0.402, 0.562, -0.586, respectively). Conclusion: High PTX3 level during an acute episode of ARF may help predict the clinical course and the severity of accompanying carditis. However, prospective studies with larger sample sizes are needed.
URI: https://doi.org/10.46497/ArchRheumatol.2021.8232
https://search.trdizin.gov.tr/yayin/detay/445762
https://hdl.handle.net/11499/46052
ISSN: 2148-5046
1309-0283
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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