Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/46148
Title: Vitamin D Deficiency Prevalence in Late Neonatal Hypocalcemia: A Multicenter Study
Authors: Seymen-Karabulut, Gulcan
Gunlemez, Ayla
Gokalp, Ayse Sevim
Hatun, Sukru
Narter, Fatma Kaya
Mutlus, Mehmet
Kader, Sebnem
Terek, Demet
Hantas, Deniz
Okulu, Emel
Karadeniz, Leyla
Zenciroglu, Aysegul
Ozdemir, Ozmert M. A.
Sarici, Dilek
Celik, Muhittin
Demir, Nihat
Turan, Ozden
Celik, Kiymet
Kilicbay, Fatih
Uslu, Sinan
Erol, Sara
Ertugrul, Sabahattin
Er, Ilkay
Celik, Hasan Tolga
Cetinkaya, Merih
Akurk-Acar, Filiz
Aslan, Yakup
Tunc, Gaffari
Guran, Omer
Arisoy, Ayse Engin
Keywords: Vitamin D deficiency
hypocalcemia
infant
newborn
Late-Onset Hypocalcemia
D Supplementation
High-Risk
Pseudohypoparathyroidism
Seizures
Children
Rickets
Infants
Publisher: Galenos Yayincilik
Abstract: Objective: Late neonatal hypocalcemia (LNH) is a common metabolic problem associated with hypoparathyroidism, high phosphate intake and vitamin D deficiency, often presenting with seizures. In this cross-sectional study, we aimed to evaluate the role of vitamin D deficiency in LNH in Turkey and to describe the characteristics of affected newborns. Methods: Conducted with a cross-sectional design and with the participation of 61 neonatal centers from December 2015 to December 2016, the study included term neonates with LNH (n=96) and their mothers (n=93). Data were registered on the FAVOR Web Registry System. Serum samples of newborns and mothers were analyzed for calcium, phosphate, magnesium, albumin, alkaline phosphatase, intact parathyroid hormone (iPTH) and 25 hydroxyvitamin D [25(OH)D] levels. Results: The median (range) onset time of hypocalcemia was 5.0 (4.0-8.0) days of age, with a male preponderance (60.4%). The median (range) serum 25(OH)D levels of the neonates and their mothers were 6.3 (4.1-9.05) and 5.2 (4.7-8.8) ng/mL, respectively. The prevalence of vitamin D deficiency (<12 ng/mL) was high in both the neonates (86.5%) and mothers (93%). Serum 25(OH)D levels of the infants and mothers showed a strong correlation (p<0.001). While the majority (93.7%) of the neonates had normal/high phosphorus levels, iPTH levels were low or inappropriately normal in 54.2% of the patients. Conclusion: Vitamin D deficiency prevalence was found to be high in LNH. Efforts to provide vitamin D supplementation during pregnancy should be encouraged. Evaluation of vitamin D status should be included in the workup of LNH.
URI: https://doi.org/10.4274/jcrpe.galenos.2020.2021.0169
https://search.trdizin.gov.tr/yayin/detay/521131
https://hdl.handle.net/11499/46148
ISSN: 1308-5727
1308-5735
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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