Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/46391
Title: Is carbonic anhydrase inhibition useful as a complementary therapy of Covid-19 infection?
Authors: Deniz, Secil
Uysal, Tugba Kevser
Capasso, Clemente
Supuran, Claudiu T.
Ozensoy Guler, Ozen
Keywords: Covid-19
CO2
hypoxia
carbonic anhydrase
high-altitude pulmonary oedema
Publisher: Taylor & Francis Ltd
Abstract: The ongoing Covid-19 is a contagious disease, and it is characterised by different symptoms such as fever, cough, and shortness of breath. Rising concerns about Covid-19 have severely affected the healthcare system in all countries as the Covid-19 outbreak has developed at a rapid rate all around the globe. Intriguing, a clinically used drug, acetazolamide (a specific inhibitor of carbonic anhydrase, CA, EC 4.2.1.1), is used to treat high-altitude pulmonary oedema (HAPE), showing a high degree of clinical similarities with the pulmonary disease caused by Covid-19. In this context, this preliminary study aims to provide insights into some factors affecting the Covid-19 patients, such as hypoxaemia, hypoxia as well as the blood CA activity. We hypothesise that patients with Covid-19 problems could show a dysregulated acid-base status influenced by CA activity. These preliminary results suggest that the use of CA inhibitors as a pharmacological treatment for Covid-19 may be beneficial.
URI: https://doi.org/10.1080/14756366.2021.1924165
https://hdl.handle.net/11499/46391
ISSN: 1475-6366
1475-6374
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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