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https://hdl.handle.net/11499/46391
Title: | Is carbonic anhydrase inhibition useful as a complementary therapy of Covid-19 infection? | Authors: | Deniz, Secil Uysal, Tugba Kevser Capasso, Clemente Supuran, Claudiu T. Ozensoy Guler, Ozen |
Keywords: | Covid-19 CO2 hypoxia carbonic anhydrase high-altitude pulmonary oedema |
Publisher: | Taylor & Francis Ltd | Abstract: | The ongoing Covid-19 is a contagious disease, and it is characterised by different symptoms such as fever, cough, and shortness of breath. Rising concerns about Covid-19 have severely affected the healthcare system in all countries as the Covid-19 outbreak has developed at a rapid rate all around the globe. Intriguing, a clinically used drug, acetazolamide (a specific inhibitor of carbonic anhydrase, CA, EC 4.2.1.1), is used to treat high-altitude pulmonary oedema (HAPE), showing a high degree of clinical similarities with the pulmonary disease caused by Covid-19. In this context, this preliminary study aims to provide insights into some factors affecting the Covid-19 patients, such as hypoxaemia, hypoxia as well as the blood CA activity. We hypothesise that patients with Covid-19 problems could show a dysregulated acid-base status influenced by CA activity. These preliminary results suggest that the use of CA inhibitors as a pharmacological treatment for Covid-19 may be beneficial. | URI: | https://doi.org/10.1080/14756366.2021.1924165 https://hdl.handle.net/11499/46391 |
ISSN: | 1475-6366 1475-6374 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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Is carbonic anhydrase inhibition useful as a complementary therapy of Covid 19 infection.pdf | 1.66 MB | Adobe PDF | View/Open |
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