Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/46391
Title: Is carbonic anhydrase inhibition useful as a complementary therapy of Covid-19 infection?
Authors: Deniz, Secil
Uysal, Tugba Kevser
Capasso, Clemente
Supuran, Claudiu T.
Ozensoy Guler, Ozen
Keywords: Covid-19
CO2
hypoxia
carbonic anhydrase
high-altitude pulmonary oedema
Publisher: Taylor & Francis Ltd
Abstract: The ongoing Covid-19 is a contagious disease, and it is characterised by different symptoms such as fever, cough, and shortness of breath. Rising concerns about Covid-19 have severely affected the healthcare system in all countries as the Covid-19 outbreak has developed at a rapid rate all around the globe. Intriguing, a clinically used drug, acetazolamide (a specific inhibitor of carbonic anhydrase, CA, EC 4.2.1.1), is used to treat high-altitude pulmonary oedema (HAPE), showing a high degree of clinical similarities with the pulmonary disease caused by Covid-19. In this context, this preliminary study aims to provide insights into some factors affecting the Covid-19 patients, such as hypoxaemia, hypoxia as well as the blood CA activity. We hypothesise that patients with Covid-19 problems could show a dysregulated acid-base status influenced by CA activity. These preliminary results suggest that the use of CA inhibitors as a pharmacological treatment for Covid-19 may be beneficial.
URI: https://doi.org/10.1080/14756366.2021.1924165
https://hdl.handle.net/11499/46391
ISSN: 1475-6366
1475-6374
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

Show full item record



CORE Recommender

SCOPUSTM   
Citations

21
checked on Oct 13, 2024

WEB OF SCIENCETM
Citations

21
checked on Nov 16, 2024

Page view(s)

40
checked on Aug 24, 2024

Download(s)

12
checked on Aug 24, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.