Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/46783
Title: The Effect of Two Different Doses of Astaxanthin on Alveolar Bone Loss in an Experimental Model of Periodontitis in Diabetic Rats
Authors: Lektemur Alpan, Aysan
Calisir, Metin
Keywords: astaxanthin
bone loss
experimental diabetes
experimental periodontitis
RANKL
Induced Oxidative Stress
Reactive Oxygen
Supplementation
Mellitus
Inflammation
Performance
Inhibition
Radicals
Healthy
Injury
Publisher: Sage Publications Inc
Abstract: This study evaluated the effects of astaxanthin (ASX) on alveolar bone loss, receptor activator of nuclear factor-kappa B ligand (RANKL), and osteoprotegerin (OPG) activity in ligature-induced periodontitis in diabetic rats. Diabetes mellitus (DM) was induced with 50 mg/kg intraperitoneal streptozotocin in 40 male Wistar rats. The Wistar rats were divided into six experimental groups: non-ligated (NL; n = 6); ligature only (L; n = 6); DM only (D; n = 6); DM + ligature (DP; n = 6); DM + ligature + 1 mg/kg/day ASX (ASX 1 group; n = 8); and DM + ligature + astaxanthin 5 mg/kg/day ASX (ASX 5 group; n = 8). Silk ligatures were placed along the gingival margin of the left mandibular first molar tooth. The study duration was 11 days, after which the animals were euthanised. Changes in alveolar bone levels were clinically measured, and RANKL and OPG activities were immunohistochemically examined. Alveolar bone loss was the most significant in the DP group (p < 0.05). Decreased alveolar bone loss was observed in the ASX 5 group (p < 0.05). Although RANKL activity was highest in the DP group, it was observed at lower levels in the groups to which ASX was administered. OPG activity did not differ between groups (p > 0.05). The results of this study suggested that 1 and 5 mg/kg ASX administration reduced RANKL activity and alveolar bone loss in rats with experimentally induced periodontitis.
URI: https://doi.org/10.1177/08987564221093736
https://hdl.handle.net/11499/46783
ISSN: 0898-7564
2470-4083
Appears in Collections:Diş Hekimliği Fakültesi Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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