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https://hdl.handle.net/11499/46941
Title: | Preparation of Diatom-Doped Bio-Nanocomposite Materials for Bone Tissue Scaffolds | Authors: | Gonenmis, Dicle Erden Ozcan, Yusuf |
Keywords: | Bio-nanocomposite Bone-tissue Diatom Scaffold Tissue engineering scaffold Biological Evaluation Mechanical-Properties Composite Scaffold Collagen Chitosan Hydroxyapatite Nanoparticles Nanotechnology Cellulose Silicon |
Publisher: | Univ Fed Sao Carlos, Dept Engenharia Materials | Abstract: | Naturally sourced materials have an important place in bone tissue engineering due to their biocompatibility and biodegradability. Non-diatom, diatom-doped chitosan/hydroxyapatite (CS/HAp) and collagen/chitosan/hydroxyapatite (Col/CS/HAp) as three-dimensional tissue scaffolds were produced by freeze drying technique. It was determined by SEM analysis that CS/HAp, CS/HAp/Di, Col/CS/ HAp, Col/CS/HAp/Di scaffolds have 160 mu m, 130 mu m, 390 mu m and 340 mu m pores, respectively. The diatoms in the structure have approximately 9-16 mu m in length, 8-20 mu m in diameter and nanopore sizes of 260-330 nm. Cell culture studies were performed using the 3T3 cell line to study the non-toxic nature of biocomposite scaffolds that support cell attachment and proliferation. The cells in the scaffolds without diatom proliferate in a reticulated manner, whereas in the scaffolds containing diatom the cells were wrapped around the scaffold like a cover. The suggested scaffolds have the potential to meet the basic requirements in biocompatibility, cytocompatibility and interconnected pore structure. | URI: | https://doi.org/10.1590/1980-5373-MR-2022-0234 https://hdl.handle.net/11499/46941 |
ISSN: | 1516-1439 1980-5373 |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Teknoloji Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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