Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/47100
Title: | Highly Porous Biocomposite Scaffolds Fabricated by Chitosan/Alginate/Diatom for Tissue Engineering | Authors: | Ozcan, Yusuf Gonenmis, Dicle Erden Kizilhan, Esranur Gok, Cem |
Keywords: | biocomposite diatom chitosan alginate scaffold tissue engineering Alginate Hydrogels Chitosan Nanoparticles Release Diatoms |
Publisher: | Polymer Soc Korea | Abstract: | Tissue scaffolds based composite material have attracted great attention in the field of bone tissue engineering. Therefore, researchers are looking for new materials to be used for composite tissue scaffolding. We aimed to produce the effect of high porous and non-toxic scaffolds as hydrogels with two different contents using chitosan, alginate and diatom. Beads were made from alginate and alginate/diatom hydrogels and additionally coated in dilute chitosan solution. Obtained alginate-chitosan (AC) and alginate/diatom-chitosan (ADC) beads were lyophilized. High-porous AC scaffold and both high-porous and nano-porous ADC scaffold were examined in terms of density, porosity, swelling tests and morphologic, chemical, cytotoxic analysis. In this study, high porosity with approximately 450 inm pore size was found for AC and ADC scaffolds. The average pore size of diatom in ADC was acquired as 280 nm. Moreover, AC and ADC did not show any cytotoxic effects on HEK293 cells. Our results clearly indicated that scaffolds have an alternative potential in the field of tissue engineering. | URI: | https://doi.org/10.7317/pk.2022.46.4.455 https://hdl.handle.net/11499/47100 |
ISSN: | 0379-153X 2234-8077 |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Teknoloji Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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