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Title: | Differences and similarities of multisystem inflammatory syndrome in children, Kawasaki disease and macrophage activating syndrome due to systemic juvenile idiopathic arthritis: a comparative study | Authors: | Otar Yener G. Paç Kısaarslan A. Ulu K. Atalay E. Haşlak F. Özdel S. Bozkaya Yücel B. Gezgin Yıldırım, Deniz Çakmak, Figen Öztürk, Kübra Çakan, Mustafa Balık, Zeynep Hasbal Akkuş, Canan Yıldız, Mehmet Erat, Tuğba Çetin, Benhur Şirvan Yılmaz, Münevver Bağlan, Esra Laçinel Gürlevik, Sibel Atasayan, Vildan Karadağ, Şerife Gül Adrovic, Amra Çağlayan, Şengül Tanatar, Ayşe Demirkan, Fatma Gül Coşkuner, Taner Akgün, Özlem Kasap Cüceoğlu, Müşerref Kavrul Kayaalp, Gülşah Şahin, Sezgin Başaran, Özge Demir, Ferhat Barut, Kenan Çiftel, Murat Gürses, Dolunay Baykan, Ali Özsürekçi, Yasemin Karagöz, Tevfik Sönmez, Hafize Emine Bilginer, Yelda Aktay Ayaz, Nuray Aydoğ, Özlem Yüksel, Selçuk Sözeri, Betül Kasapçopur, Özgür Özen, Seza |
Keywords: | Kawasaki disease (KD) Macrophage activation syndrome Multisystem inflammatory syndrome in children (MIS-C) Systemic juvenile idiopathic arthritis alanine aminotransferase aspartate aminotransferase brain natriuretic peptide D dimer ferritin hemoglobin biological marker ferritin Article child controlled study female ferritin blood level hospitalization human human cell inflammation leukocyte count lymphocyte count macrophage activation syndrome major clinical study male mucocutaneous lymph node syndrome neutrophil count platelet count systemic inflammatory response syndrome systemic juvenile idiopathic arthritis thrombocyte complication juvenile rheumatoid arthritis macrophage macrophage activation syndrome mucocutaneous lymph node syndrome systemic inflammatory response syndrome Arthritis, Juvenile Biomarkers Child COVID-19 Ferritins Humans Macrophage Activation Syndrome Macrophages Mucocutaneous Lymph Node Syndrome Systemic Inflammatory Response Syndrome |
Publisher: | Springer Science and Business Media Deutschland GmbH | Abstract: | To compare the clinical and laboratory findings of multisystem inflammatory syndrome in children (MIS-C), patients with Kawasaki disease (KD) and with macrophage activating syndrome due to systemic juvenile idiopathic arthritis (sJIA-MAS) on real-life data. Patients diagnosed with MIS-C, KD, and sJIA-MAS from 12 different centers in Turkey who were followed for at least 6 months were included in the study. Demographic, clinical, and laboratory findings of all patients were analyzed. A total of 154 MIS-C, 59 KD, and 31 sJIA-MAS patients were included. The median age of patients with MIS-C were higher than those with KD while lower than those with sJIA-MAS (8.2, 3, 12 years, respectively). Myalgia (39.6%), cardiac (50.6%), gastrointestinal (72.7%), and neurological (22.1%) involvements were more common in patients with MIS-C compared to others. MIS-C patients had lower levels of lymphocyte (950 vs 1700 cells/µl) and thrombocyte (173,000 vs 355,000 cells/µl) counts and higher pro-BNP (1108 vs 55 pg/ml) levels than KD. Ferritin levels were higher in patients with MIS-C compared to patients with KD while they were lower than patients with sJIA-MAS (440, 170, 10,442 ng/ml, respectively). Patients with MIS-C had a shorter duration of hospitalization than sJIA-MAS (p = 0.02) while they required intensive care unit admission more frequently (55 vs 8 patients, p < 0.001). The median MAS/sJIA score of MIS-C patients was ? 1.64 (? 5.23 to 9.68) and the median MAS/sJIA score of sJIA-MAS patients was ?2.81 ([? 3.79] to [? 1.27]). MIS-C patients displayed certain differences in clinical and laboratory features when compared to KD and sJIA-MAS. Definition of the differences and similarities between MIS-C and the other intense inflammatory syndromes of childhood such as KD and MAS will help the clinicians while making timely diagnosis. © 2021, The Author(s), under exclusive licence to Springer-Verlag GmbH Germany, part of Springer Nature. | URI: | https://doi.org/10.1007/s00296-021-04980-7 https://hdl.handle.net/11499/47351 |
ISSN: | 0172-8172 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu |
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