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https://hdl.handle.net/11499/47468
Title: | Soluble P-Selectin as a Potential Diagnostic and Prognostic Biomarker for Covid-19 Disease: a Case-Control Study | Authors: | Karsli, Emre Sabirli, Ramazan Altintas, Emel Canacik, Omer Sabirli, Gizem Tukenmez Kaymaz, Buse Koseler, Aylin |
Keywords: | Serum Soluble P-Selectin Levels Covid-19 Infection Pneumonia |
Publisher: | Pergamon-elsevier Science Ltd | Abstract: | Introduction: To our knowledge, the diagnostic value of the sP-Selectin level in the diagnosis of COVID-19 disease has not yet been investigated. In this study, we aimed to assess this by evaluating the relationship between sPSelectin level and the clinical severity of COVID-19 infections. Methods: A total of 80 patients (50 with mild to moderate and 30 with severe COVID-19 pneumonia), and 60 nonsymptomatic healthy volunteers participated in the study. Following serum isolation, sP-Selectin levels were assessed by Enzyme-Linked Immunosorbent Assay (ELISA) method. Results: The serum sP-Selectin level was 1.7 ng/ml in the control group (1-3.78); 6.24 ng/ml (5.14-7.23) in mildto-moderate pneumonia group; and 6.72 ng/ml (5.36-8.03) in the severe pneumonia group. Serum sP-Selectin levels in both mild-to-moderate pneumonia and severe pneumonia groups were found to be higher than the control group, with statistical significance (p = 0.0001 and p = 0.0001, respectively). Receiver operating characteristic analysis (ROC) showed greater area under the curve (AUC) for the serum sPSelectin levels of the COVID-19 patients (AUC = 0.913, 95% CI = 0.857-0.969; p = 0.0001). The serum sPSelectin level was found to be 97.5% sensitive and 80% specific at 4.125 ng/ml level for diagnosis (p = 0.0001). The serum sP-Selectin level was found to be 76.9% sensitive and 51.9% specific at the level of 6.12 ng/ ml (p = 0.005) to predict the need for intensive care treatment. Conclusion: This study showed that sP-Selectin can be used as a valuable biomarker in both diagnosing and predicting the need for intensive care treatment of COVID-19 infection. | Description: | Koseler, Aylin/0000-0003-4832-0436; Kurt, Ozgur/0000-0001-5575-588X | URI: | https://doi.org/10.1016/j.lfs.2021.119634 | ISSN: | 0024-3205 1879-0631 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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