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https://hdl.handle.net/11499/47490
Title: | Relationships of 18F-FDG uptake by primary tumors with prognostic factors and molecular subtype in ductal breast cancer | Other Titles: | Correlación entre la captación de 18F-FDG del tumor primario con los factores pronósticos y subtipo molecular del cáncer ductal de mama | Authors: | Sengöz T. Karakaya Y.A. Gültekin A. Yaylali O. Senol H. Yuksel D. |
Keywords: | 18F-FDG Ductal breast cancer Molecular subtype p53 SUVmax fluorodeoxyglucose f 18 hormone receptor Ki 67 antigen Article axillary lymph node axillary lymphadenopathy basal subtype breast cancer breast cancer breast cancer molecular subtype cancer grading cancer patient cancer prognosis cancer staging correlational study distant metastasis female histopathology human invasive ductal breast carcinoma luminal A breast cancer lymphadenopathy major clinical study maximum standardized uptake value positron emission tomography-computed tomography prediction primary tumor retrospective study tumor volume breast tumor diagnostic imaging prognosis Breast Neoplasms Female Fluorodeoxyglucose F18 Humans Positron Emission Tomography Computed Tomography Prognosis Retrospective Studies |
Publisher: | Ediciones Doyma, S.L. | Abstract: | Objectives: In this study, we aimed to investigate the correlation between SUVmax of primary tumor and prognostic factors/molecular subtype in ductal breast cancer patients. Materials and methods: We retrospectively reviewed 150 female patients with pathologically proven invasive ductal breast cancer from January 2015 to October 2019 who underwent 18F-FDG PET/CT for initial staging. Histopathological prognostic features of the primary tumor (histological grade, hormone receptor status, Ki-67 index, vb.) were obtained from the tru-cut biopsy report. In 18F-FDG PET/CT studies, the maximum standardized uptake value (SUVmax) of the primary breast tumor was calculated and compared with the presence of axillary lymphadenopathy and/or distant metastases, histopathological prognostic factors and molecular subtype. Results: The high SUVmax of primary breast tumors is significantly correlated with the clinicopathological factors: high tumor size, high histologic grade, high Ki-67 index, axillary lymph node positivity and distant metastasis. SUVmax value was significantly higher in patients with basal subtype than patients with Luminal A subtype (8.14 ± 3.71 and 4.64 ± 2.45, p = 0.002). Correlation analysis revealed a low correlation between Ki-67 index and SUVmax (r = 0.276, p = 0.001) and moderate correlation between tumor size and SUVmax (r = 0.470, p = 0.001). In multivariate linear regression analysis, Ki-67 index and tumor size had a statistically significant effect on SUVmax values. As these parameters increase, it is seen that it increases SUVmax values (p = 0.004, Std Beta: 0.228, 95% CI: 0.010–0.055 and p = 0.001, Std Beta: 0.374, 95% CI: 0.55–0.136, respectively). Conclusión: High SUVmax value is associated with prognotic factors suggesting poor prognosis. Pretreatment 18F-FDG PET/CT can be used as a tool to predict prognosis in breast cancer. © 2021 Sociedad Española de Medicina Nuclear e Imagen Molecular | URI: | https://doi.org/10.1016/j.remn.2020.11.006 https://hdl.handle.net/11499/47490 |
ISSN: | 2253-654X |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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