Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/47545
Title: New Cytotoxic Chalcone Derivatives From Astragalus Ponticus Pall
Authors: Koldas, Serkan
Demirtas, Ibrahim
Mutlu, Dogukan
Atalar, Mehmet Nuri
Unver, Hakan
Arslan, Sevki
Keywords: Antiproliferative Activity
Astragalus Ponticus Pall
Characterization
Hela
Isolation
Natural Products
Publisher: Taylor & Francis Ltd
Abstract: Astragalus ponticus Pall. species was investigated for its antiproliferative effects on HeLa cells. Two new chalcones (B5 and B8) along with eight known compounds (B1, B2, B3, B6, B7, B10, B14 and B15) were isolated by following bioactivity guided isolation methods. In addition, from non-active fraction, three cycloartane glycosides (B11, B12 and B13) were isolated. Molecular structures of these isolated compounds were revealed by using spectroscopic methods like MS, 1D and 2D NMR and a single crystal X-ray diffraction analysis. New compounds B5 and B8 showed the highest antiproliferative activities against HeLa cells (IC50 values of 36.6 and 20.6 mu M, respectively) while the rest showed high and low activities. Non-endemic species attract relatively low attention from the scientific community but this study demonstrates that valuable new compounds, which might be used as ingredients in medicinal preparations, can be obtained from these materials.
Description: Atalar, Mehmet Nuri/0000-0003-2993-2605; Demirtas, Ibrahim/0000-0001-8946-647X; Mutlu, Dogukan/0000-0003-3259-5822; Koldas, Serkan/0000-0002-7917-4008
URI: https://doi.org/10.1080/14786419.2021.2012771
ISSN: 1478-6419
1478-6427
Appears in Collections:Fen-Edebiyat Fakültesi Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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