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https://hdl.handle.net/11499/47545
Title: | New cytotoxic chalcone derivatives from Astragalus ponticus Pall. | Authors: | Koldaş, Serkan Demirtaş, İbrahim Mutlu, Doğukan Atalar, Mehmet Nuri Ünver, Hakan Arslan, Şevki |
Keywords: | Antiproliferative activity Astragalus ponticusPall characterization HeLa isolation natural products chalcone derivative natural product chalcone chalcone derivative glycoside antiproliferative activity Article Astragalus (plant) Astragalus ponticus Pall attention biological activity chemical structure conformation crystal structure HeLa cell line IC50 isolation nuclear magnetic resonance spectroscopy X ray diffraction chemistry human Astragalus Plant Chalcone Chalcones Glycosides HeLa Cells Humans Molecular Structure |
Publisher: | Taylor and Francis Ltd. | Abstract: | Astragalus ponticus Pall. species was investigated for its antiproliferative effects on HeLa cells. Two new chalcones (B5 and B8) along with eight known compounds (B1, B2, B3, B6, B7, B10, B14 and B15) were isolated by following bioactivity guided isolation methods. In addition, from non-active fraction, three cycloartane glycosides (B11, B12 and B13) were isolated. Molecular structures of these isolated compounds were revealed by using spectroscopic methods like MS, 1D and 2D NMR and a single crystal X-ray diffraction analysis. New compounds B5 and B8 showed the highest antiproliferative activities against HeLa cells (IC50 values of 36.6 and 20.6 µM, respectively) while the rest showed high and low activities. Non-endemic species attract relatively low attention from the scientific community but this study demonstrates that valuable new compounds, which might be used as ingredients in medicinal preparations, can be obtained from these materials. © 2021 Informa UK Limited, trading as Taylor & Francis Group. | URI: | https://doi.org/10.1080/14786419.2021.2012771 https://hdl.handle.net/11499/47545 |
ISSN: | 1478-6419 |
Appears in Collections: | Fen-Edebiyat Fakültesi Koleksiyonu PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection |
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gnpl_a_2012771_sm9862.docx | 5.11 MB | Microsoft Word XML | View/Open |
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