Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/47690
Title: Synthesis, Cytotoxicity, Antioxidant and Antimicrobial Activity of Indole Based Novel Small Molecules
Authors: Kurt-Kizildogan, Aslihan
Otur, Cigdem
Yilmaz, Can
Arslan, Sevki
Mutlu, Dogukan
Kivrak, Arif
Konus, Metin
Keywords: Indole
Heteroaromatic Compounds
Antioxidant
Cytotoxicity
Antimicrobial
Small Molecules
Publisher: Bentham Science Publ Ltd
Abstract: Aims: In this study experiments were carried out to explore antioxidant, antimicrobial, cytotoxic properties of novel indole derivative 1-ethyl-2-phenyl-3-phenylethyl-3-thiophen-2-yl-1Hindole (EPI) together with its effect on glutathione S-transferases (GST) activities in human liver carcinoma (HepG2) cells. Background: Indoles probably represent one of the most important heterocyclic structures that have been attracting the interest of many scientists in drug discovery. Objective: The present study was carried out to explore antioxidant, antimicrobial, cytotoxic properties of novel indole derivative 1-ethyl-2-phenyl-3-phenylethyl-3-thiophen-2-yl-1H-indole (EPI) and its effect on glutathione S-transferases (GST) activities in human liver carcinoma (HepG2) cells. Materials and Methods: Pd-catalyst Sonogashira coupling reactions, MTT Assay, Antioxidant capacity test, Antimicrobial test, GST enzyme activity test Results: 1-ethyl-2-phenyl-3-(phenylethynyl)-1H-indole had antioxidant and antimicrobial properties. It displayed significant induction in glutathione S-transferases (GST) enzyme activity in human liver cancer cell lines (HepG2), but cytotoxic effect on all tested cancer cell lines could not be observed. Conclusion: All of these results showed that 1-ethyl-2-phenyl-3-(phenylethynyl)-1H-indole had antioxidant and antimicrobial properties without cytotoxic effect, which could make it a promising active component with further studies..
Description: Konus, Metin/0000-0002-9953-1375; Cetin, Dogan/0000-0002-5733-4007; Mutlu, Dogukan/0000-0003-3259-5822; Kurt Kizildogan, Aslihan/0000-0002-9323-0993; Kivrak, Arif/0000-0003-4770-2686
URI: https://doi.org/10.2174/1570180817999201109203226
ISSN: 1570-1808
1875-628X
Appears in Collections:Fen-Edebiyat Fakültesi Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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