Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4774
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dc.contributor.authorTurgut, Hüseyin-
dc.contributor.authorSaçar, Suzan-
dc.contributor.authorKaleli, İlknur-
dc.contributor.authorSaçar, Mustafa-
dc.contributor.authorGökşin, İbrahim-
dc.contributor.authorToprak, Semra-
dc.contributor.authorAsan, Ali-
dc.date.accessioned2019-08-16T11:37:09Z
dc.date.available2019-08-16T11:37:09Z
dc.date.issued2005-
dc.identifier.issn1471-2334-
dc.identifier.urihttps://hdl.handle.net/11499/4774-
dc.identifier.urihttps://doi.org/10.1186/1471-2334-5-91-
dc.description.abstractBackground: The aim of the study was to investigate the in vivo efficacy of local and systemic antibiotic prophylaxis in the prevention of Staphylococcus (S.) epidermidis graft infection in a rat model and to evaluate the bacterial adherence to frequently used prosthetic graft materials. Methods: Graft infections were established in the subcutaneous tissue of 120 male Wistar rats by implantation of Dacron/ePTFE grafts followed by topical inoculation with 2×107 CFUS of clinical isolate of methicillin-resistant S. epidermidis. Each of the graft series included a control group, one contaminated group that did not receive any antibiotic prophylaxis, two contaminated groups that received systemic prophylaxis with teicoplanin or levofloxacin and two contaminated groups that received teicoplanin-soaked or levofloxacin-soaked grafts. The grafts were removed 7 days after implantation and evaluated by quantitative culture. Results: There was significant bacterial growth inhibition in the groups given systemic or local prophylaxis (P<0.05). Methicillin-resistant S. epidermidis had greater affinity to Dacron graft when compared with ePTFE graft in the untreated contaminated groups (P<0.05). Conclusions: The study demonstrated that the usage of systemic or local prophylaxis and preference of ePTFE graft can be useful in reducing the risk of vascular graft infections caused by staphylococcal strains with high levels of resistance. © 2005 Turgut et al., licensee BioMed Central Ltd.en_US
dc.language.isoenen_US
dc.relation.ispartofBMC Infectious Diseasesen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectantibiotic agenten_US
dc.subjectdacronen_US
dc.subjectlevofloxacinen_US
dc.subjectmeticillinen_US
dc.subjectpolitefen_US
dc.subjectteicoplaninen_US
dc.subjectantiinfective agenten_US
dc.subjectofloxacinen_US
dc.subjectpolyethylene terephthalateen_US
dc.subjectanimal experimenten_US
dc.subjectanimal modelen_US
dc.subjectantibiotic prophylaxisen_US
dc.subjectantibiotic resistanceen_US
dc.subjectarticleen_US
dc.subjectbacterial growthen_US
dc.subjectbacterium adherenceen_US
dc.subjectbacterium cultureen_US
dc.subjectblood vessel graften_US
dc.subjectblood vessel prosthesisen_US
dc.subjectcontrolled studyen_US
dc.subjectdrug efficacyen_US
dc.subjectfrequency analysisen_US
dc.subjectgraft infectionen_US
dc.subjectgrowth inhibitionen_US
dc.subjectin vivo studyen_US
dc.subjectinfection preventionen_US
dc.subjectinoculationen_US
dc.subjectmaleen_US
dc.subjectnonhumanen_US
dc.subjectprosthesis materialen_US
dc.subjectquantitative analysisen_US
dc.subjectraten_US
dc.subjectrat strainen_US
dc.subjectrisk reductionen_US
dc.subjectStaphylococcus epidermidisen_US
dc.subjectStaphylococcus infectionen_US
dc.subjectsubcutaneous tissueen_US
dc.subjectanimalen_US
dc.subjectblood vessel transplantationen_US
dc.subjectdrug effecten_US
dc.subjectinfectionen_US
dc.subjectmicrobiologyen_US
dc.subjectpenicillin resistanceen_US
dc.subjectWistar raten_US
dc.subjectAnimalsen_US
dc.subjectAnti-Bacterial Agentsen_US
dc.subjectAntibiotic Prophylaxisen_US
dc.subjectBlood Vessel Prosthesisen_US
dc.subjectBlood Vessel Prosthesis Implantationen_US
dc.subjectMaleen_US
dc.subjectMethicillin Resistanceen_US
dc.subjectOfloxacinen_US
dc.subjectPolyethylene Terephthalatesen_US
dc.subjectPolytetrafluoroethyleneen_US
dc.subjectProsthesis-Related Infectionsen_US
dc.subjectRatsen_US
dc.subjectRats, Wistaren_US
dc.subjectStaphylococcal Infectionsen_US
dc.subjectTeicoplaninen_US
dc.titleSystemic and local antibiotic prophylaxis in the prevention of Staphylococcus epidermidis graft infectionen_US
dc.typeArticleen_US
dc.identifier.volume5en_US
dc.authorid0000-0001-8764-7701-
dc.identifier.doi10.1186/1471-2334-5-91-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid16242027en_US
dc.identifier.scopus2-s2.0-27744506191en_US
dc.identifier.wosWOS:000232924000001en_US
dc.identifier.scopusqualityQ2-
dc.ownerPamukkale_University-
item.cerifentitytypePublications-
item.languageiso639-1en-
item.grantfulltextopen-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.fulltextWith Fulltext-
item.openairetypeArticle-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.01. Surgical Medicine-
crisitem.author.dept14.01. Surgical Medicine-
crisitem.author.dept29. Denizli Health Services Vocational School of Higher Education-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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