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https://hdl.handle.net/11499/4774
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DC Field | Value | Language |
---|---|---|
dc.contributor.author | Turgut, Hüseyin | - |
dc.contributor.author | Saçar, Suzan | - |
dc.contributor.author | Kaleli, İlknur | - |
dc.contributor.author | Saçar, Mustafa | - |
dc.contributor.author | Gökşin, İbrahim | - |
dc.contributor.author | Toprak, Semra | - |
dc.contributor.author | Asan, Ali | - |
dc.date.accessioned | 2019-08-16T11:37:09Z | |
dc.date.available | 2019-08-16T11:37:09Z | |
dc.date.issued | 2005 | - |
dc.identifier.issn | 1471-2334 | - |
dc.identifier.uri | https://hdl.handle.net/11499/4774 | - |
dc.identifier.uri | https://doi.org/10.1186/1471-2334-5-91 | - |
dc.description.abstract | Background: The aim of the study was to investigate the in vivo efficacy of local and systemic antibiotic prophylaxis in the prevention of Staphylococcus (S.) epidermidis graft infection in a rat model and to evaluate the bacterial adherence to frequently used prosthetic graft materials. Methods: Graft infections were established in the subcutaneous tissue of 120 male Wistar rats by implantation of Dacron/ePTFE grafts followed by topical inoculation with 2×107 CFUS of clinical isolate of methicillin-resistant S. epidermidis. Each of the graft series included a control group, one contaminated group that did not receive any antibiotic prophylaxis, two contaminated groups that received systemic prophylaxis with teicoplanin or levofloxacin and two contaminated groups that received teicoplanin-soaked or levofloxacin-soaked grafts. The grafts were removed 7 days after implantation and evaluated by quantitative culture. Results: There was significant bacterial growth inhibition in the groups given systemic or local prophylaxis (P<0.05). Methicillin-resistant S. epidermidis had greater affinity to Dacron graft when compared with ePTFE graft in the untreated contaminated groups (P<0.05). Conclusions: The study demonstrated that the usage of systemic or local prophylaxis and preference of ePTFE graft can be useful in reducing the risk of vascular graft infections caused by staphylococcal strains with high levels of resistance. © 2005 Turgut et al., licensee BioMed Central Ltd. | en_US |
dc.language.iso | en | en_US |
dc.relation.ispartof | BMC Infectious Diseases | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | antibiotic agent | en_US |
dc.subject | dacron | en_US |
dc.subject | levofloxacin | en_US |
dc.subject | meticillin | en_US |
dc.subject | politef | en_US |
dc.subject | teicoplanin | en_US |
dc.subject | antiinfective agent | en_US |
dc.subject | ofloxacin | en_US |
dc.subject | polyethylene terephthalate | en_US |
dc.subject | animal experiment | en_US |
dc.subject | animal model | en_US |
dc.subject | antibiotic prophylaxis | en_US |
dc.subject | antibiotic resistance | en_US |
dc.subject | article | en_US |
dc.subject | bacterial growth | en_US |
dc.subject | bacterium adherence | en_US |
dc.subject | bacterium culture | en_US |
dc.subject | blood vessel graft | en_US |
dc.subject | blood vessel prosthesis | en_US |
dc.subject | controlled study | en_US |
dc.subject | drug efficacy | en_US |
dc.subject | frequency analysis | en_US |
dc.subject | graft infection | en_US |
dc.subject | growth inhibition | en_US |
dc.subject | in vivo study | en_US |
dc.subject | infection prevention | en_US |
dc.subject | inoculation | en_US |
dc.subject | male | en_US |
dc.subject | nonhuman | en_US |
dc.subject | prosthesis material | en_US |
dc.subject | quantitative analysis | en_US |
dc.subject | rat | en_US |
dc.subject | rat strain | en_US |
dc.subject | risk reduction | en_US |
dc.subject | Staphylococcus epidermidis | en_US |
dc.subject | Staphylococcus infection | en_US |
dc.subject | subcutaneous tissue | en_US |
dc.subject | animal | en_US |
dc.subject | blood vessel transplantation | en_US |
dc.subject | drug effect | en_US |
dc.subject | infection | en_US |
dc.subject | microbiology | en_US |
dc.subject | penicillin resistance | en_US |
dc.subject | Wistar rat | en_US |
dc.subject | Animals | en_US |
dc.subject | Anti-Bacterial Agents | en_US |
dc.subject | Antibiotic Prophylaxis | en_US |
dc.subject | Blood Vessel Prosthesis | en_US |
dc.subject | Blood Vessel Prosthesis Implantation | en_US |
dc.subject | Male | en_US |
dc.subject | Methicillin Resistance | en_US |
dc.subject | Ofloxacin | en_US |
dc.subject | Polyethylene Terephthalates | en_US |
dc.subject | Polytetrafluoroethylene | en_US |
dc.subject | Prosthesis-Related Infections | en_US |
dc.subject | Rats | en_US |
dc.subject | Rats, Wistar | en_US |
dc.subject | Staphylococcal Infections | en_US |
dc.subject | Teicoplanin | en_US |
dc.title | Systemic and local antibiotic prophylaxis in the prevention of Staphylococcus epidermidis graft infection | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 5 | en_US |
dc.authorid | 0000-0001-8764-7701 | - |
dc.identifier.doi | 10.1186/1471-2334-5-91 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 16242027 | en_US |
dc.identifier.scopus | 2-s2.0-27744506191 | en_US |
dc.identifier.wos | WOS:000232924000001 | en_US |
dc.identifier.scopusquality | Q2 | - |
dc.owner | Pamukkale_University | - |
item.cerifentitytype | Publications | - |
item.languageiso639-1 | en | - |
item.grantfulltext | open | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.fulltext | With Fulltext | - |
item.openairetype | Article | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.03. Basic Medical Sciences | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
crisitem.author.dept | 14.01. Surgical Medicine | - |
crisitem.author.dept | 29. Denizli Health Services Vocational School of Higher Education | - |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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