Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/4774
Title: | Systemic and local antibiotic prophylaxis in the prevention of Staphylococcus epidermidis graft infection | Authors: | Turgut, Hüseyin Saçar, Suzan Kaleli, İlknur Saçar, Mustafa Gökşin, İbrahim Toprak, Semra Asan, Ali |
Keywords: | antibiotic agent dacron levofloxacin meticillin politef teicoplanin antiinfective agent ofloxacin polyethylene terephthalate animal experiment animal model antibiotic prophylaxis antibiotic resistance article bacterial growth bacterium adherence bacterium culture blood vessel graft blood vessel prosthesis controlled study drug efficacy frequency analysis graft infection growth inhibition in vivo study infection prevention inoculation male nonhuman prosthesis material quantitative analysis rat rat strain risk reduction Staphylococcus epidermidis Staphylococcus infection subcutaneous tissue animal blood vessel transplantation drug effect infection microbiology penicillin resistance Wistar rat Animals Anti-Bacterial Agents Antibiotic Prophylaxis Blood Vessel Prosthesis Blood Vessel Prosthesis Implantation Male Methicillin Resistance Ofloxacin Polyethylene Terephthalates Polytetrafluoroethylene Prosthesis-Related Infections Rats Rats, Wistar Staphylococcal Infections Teicoplanin |
Abstract: | Background: The aim of the study was to investigate the in vivo efficacy of local and systemic antibiotic prophylaxis in the prevention of Staphylococcus (S.) epidermidis graft infection in a rat model and to evaluate the bacterial adherence to frequently used prosthetic graft materials. Methods: Graft infections were established in the subcutaneous tissue of 120 male Wistar rats by implantation of Dacron/ePTFE grafts followed by topical inoculation with 2×107 CFUS of clinical isolate of methicillin-resistant S. epidermidis. Each of the graft series included a control group, one contaminated group that did not receive any antibiotic prophylaxis, two contaminated groups that received systemic prophylaxis with teicoplanin or levofloxacin and two contaminated groups that received teicoplanin-soaked or levofloxacin-soaked grafts. The grafts were removed 7 days after implantation and evaluated by quantitative culture. Results: There was significant bacterial growth inhibition in the groups given systemic or local prophylaxis (P<0.05). Methicillin-resistant S. epidermidis had greater affinity to Dacron graft when compared with ePTFE graft in the untreated contaminated groups (P<0.05). Conclusions: The study demonstrated that the usage of systemic or local prophylaxis and preference of ePTFE graft can be useful in reducing the risk of vascular graft infections caused by staphylococcal strains with high levels of resistance. © 2005 Turgut et al., licensee BioMed Central Ltd. | URI: | https://hdl.handle.net/11499/4774 https://doi.org/10.1186/1471-2334-5-91 |
ISSN: | 1471-2334 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Files in This Item:
File | Size | Format | |
---|---|---|---|
1471-2334-5-91.pdf | 257.82 kB | Adobe PDF | View/Open |
CORE Recommender
SCOPUSTM
Citations
27
checked on Oct 13, 2024
WEB OF SCIENCETM
Citations
23
checked on Oct 31, 2024
Page view(s)
62
checked on Aug 24, 2024
Download(s)
16
checked on Aug 24, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.