Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4774
Title: Systemic and local antibiotic prophylaxis in the prevention of Staphylococcus epidermidis graft infection
Authors: Turgut, Hüseyin
Saçar, Suzan
Kaleli, İlknur
Saçar, Mustafa
Gökşin, İbrahim
Toprak, Semra
Asan, Ali
Keywords: antibiotic agent
dacron
levofloxacin
meticillin
politef
teicoplanin
antiinfective agent
ofloxacin
polyethylene terephthalate
animal experiment
animal model
antibiotic prophylaxis
antibiotic resistance
article
bacterial growth
bacterium adherence
bacterium culture
blood vessel graft
blood vessel prosthesis
controlled study
drug efficacy
frequency analysis
graft infection
growth inhibition
in vivo study
infection prevention
inoculation
male
nonhuman
prosthesis material
quantitative analysis
rat
rat strain
risk reduction
Staphylococcus epidermidis
Staphylococcus infection
subcutaneous tissue
animal
blood vessel transplantation
drug effect
infection
microbiology
penicillin resistance
Wistar rat
Animals
Anti-Bacterial Agents
Antibiotic Prophylaxis
Blood Vessel Prosthesis
Blood Vessel Prosthesis Implantation
Male
Methicillin Resistance
Ofloxacin
Polyethylene Terephthalates
Polytetrafluoroethylene
Prosthesis-Related Infections
Rats
Rats, Wistar
Staphylococcal Infections
Teicoplanin
Abstract: Background: The aim of the study was to investigate the in vivo efficacy of local and systemic antibiotic prophylaxis in the prevention of Staphylococcus (S.) epidermidis graft infection in a rat model and to evaluate the bacterial adherence to frequently used prosthetic graft materials. Methods: Graft infections were established in the subcutaneous tissue of 120 male Wistar rats by implantation of Dacron/ePTFE grafts followed by topical inoculation with 2×107 CFUS of clinical isolate of methicillin-resistant S. epidermidis. Each of the graft series included a control group, one contaminated group that did not receive any antibiotic prophylaxis, two contaminated groups that received systemic prophylaxis with teicoplanin or levofloxacin and two contaminated groups that received teicoplanin-soaked or levofloxacin-soaked grafts. The grafts were removed 7 days after implantation and evaluated by quantitative culture. Results: There was significant bacterial growth inhibition in the groups given systemic or local prophylaxis (P<0.05). Methicillin-resistant S. epidermidis had greater affinity to Dacron graft when compared with ePTFE graft in the untreated contaminated groups (P<0.05). Conclusions: The study demonstrated that the usage of systemic or local prophylaxis and preference of ePTFE graft can be useful in reducing the risk of vascular graft infections caused by staphylococcal strains with high levels of resistance. © 2005 Turgut et al., licensee BioMed Central Ltd.
URI: https://hdl.handle.net/11499/4774
https://doi.org/10.1186/1471-2334-5-91
ISSN: 1471-2334
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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