Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/47773
Title: Secondary infections in COVID-19 patients: A two-centre retrospective observational study
Authors: Menekse S.
Deniz S.
Keywords: Carbapenem resistance
COVID-19
Intensive care unit infections.
Secondary infections
carbapenem
convalescent plasma
procalcitonin
steroid
tocilizumab
carbapenem derivative
Acinetobacter baumannii
adult
adult respiratory distress syndrome
aged
antibiotic sensitivity
APACHE
Article
bacterium
Candida
carbapenem resistance
coagulase negative Staphylococcus
coronavirus disease 2019
days from diagnosis to discharge or mortality
duration of central catheter
duration of extracorporeal oxygenation
duration of invasive ventilation
Enterobacter aerogenes
Enterococcus
Escherichia coli
extracorporeal oxygenation
female
Horowitz index
human
intensive care unit
Klebsiella pneumoniae
length of stay
male
methicillin resistant Staphylococcus aureus
methicillin susceptible Staphylococcus aureus
microbiological examination
mortality rate
observational study
physical parameters
Providencia rettgeri
Pseudomonas aeruginosa
retrospective study
secondary infection
septic shock
Sequential Organ Failure Assessment Score
Serratia marcescens
Sphingomona paucimobilis
Stenotrophomonas maltophilia
adolescent
coinfection
epidemiology
middle aged
Adolescent
Carbapenems
Coinfection
COVID-19
Female
Humans
Intensive Care Units
Male
Middle Aged
Retrospective Studies
Publisher: Journal of Infection in Developing Countries
Abstract: Introduction: We sought to evaluate secondary infections (SIs) in patients admitted to the intensive care unit (ICU) for COVID-19 with respect to incidence, causative pathogens, and clinical outcomes. Methodology: In this two-centre retrospective study, we analysed 146 patients (96 males, 50 females; median age, 64 years) admitted to the ICU with COVID-19 between March 26 and December 31, 2020. Inclusion criteria were an ICU admission for at least 48 hours and age beyond 18 years. Patients with and without SIs were compared and the impacts of SIs and carbapenem resistance on mortality were analysed. Results: During ICU admission, 84 episodes of SIs developed in 58 patients (39.7%). A total of 104 isolates were recovered, with Gram-negative bacteria most frequent accounting for 74%. At least one carbapenem-resistant pathogen (n = 61) was recovered in 41 patients (70.1%). In multivariate analysis, the use of ECMO and an elevated procalcitonin level were significantly associated with the development of SIs. The mortality rate and the incidence of carbapenem resistance did not differ significantly in COVID-19 patients with and without SIs (p = 0.059 and p = 0.083, respectively). Conclusions: The incidences of SIs and carbapenem resistance among COVID-19 patients were alarming, emphasizing stricter infection control measures in the ICU setting. © 2022 Journal of Infection in Developing Countries. All rights reserved.
URI: https://doi.org/10.3855/jidc.15637
https://hdl.handle.net/11499/47773
ISSN: 2036-6590
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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