Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/47853
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dc.contributor.authorGökşin, Şule-
dc.contributor.authorÇayır, Mustafa Çağdaş-
dc.date.accessioned2023-01-09T21:30:25Z-
dc.date.available2023-01-09T21:30:25Z-
dc.date.issued2022-
dc.identifier.issn1300-0330-
dc.identifier.urihttps://doi.org/10.5336/dermato.2022-90463-
dc.identifier.urihttps://hdl.handle.net/11499/47853-
dc.description.abstractObjective: Epidermal growth factor (EGF) plays an important role in wound healing. But, bioavailability of EGF is impaired in chronic diabetic foot ulcer (CDFU) due to increased protease activity. The study's objective was to evaluate the effect of intralesional human-EGF (h-EGF) on wound healing in patients with CDFU. Material and Methods: Twenty-eight patients with CDFU were included to study. 75 µg intralesional h-EGF thrice a week for 5 weeks were used to accelerate wound healing. Ulcer size was calculated by simple planimetric measurement. Specimens for culture were taken from all patients. Granulation response were evaluated with healing grade (HG) [HG-0 ? no response, HG-I ? minimal response, HG-II ? partial response, HG-III ? complete response] and complete wound closure. Pre- and post-treatment ulcers size were recorded to asses treatment outcome. Results: New granulation tissue over the wound (HG I-III) was present in 26 (92.8%) patients at the end of treatment. Complete wound healing (HG III) was achieved in 10 (35.7%) patients, complete wound closure was seen in 3 (10.7%) patients. Pre and post-treatment mean ulcers size were 23.9±18.5 and 6.5±4.8 cm2 (p=0.001). The most frequent adverse events of h-EGF were tremor (32.1%). Total of 47 causative bacterias (14 different types of bacteria) were isolated from 23 (87.2%) patients, whereas cultures were sterile in 5 (17.8%) of the patients. Primarily, Escherichia coli, Proteus mirabilis, Acinetobacter baumannii, Pseudomonas aeruginosa species were seen in rate of 19.1%, 17%, 12.7%, 10.6% respectively. Conclusion: Intralesional h-EGF is effective in the treatment of CDFU, has no serious side-effect and accelerates wound healing. Copyright © 2022 by Türkiye Klinikleri.en_US
dc.language.isoenen_US
dc.publisherOrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S.en_US
dc.relation.ispartofTurkiye Klinikleri Dermatolojien_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectadverse effecten_US
dc.subjectcultureen_US
dc.subjectdiabetic footen_US
dc.subjectEpidermal growth factoren_US
dc.subjectwound healingen_US
dc.subjectgamma urogastroneen_US
dc.subjecthemoglobin A1cen_US
dc.subjectinsulinen_US
dc.subjectoral antidiabetic agenten_US
dc.subjectAcinetobacter baumanniien_US
dc.subjectAcinetobacter calcoaceticusen_US
dc.subjectadulten_US
dc.subjectadverse drug reactionen_US
dc.subjectageden_US
dc.subjectArticleen_US
dc.subjectbacterium cultureen_US
dc.subjectbacterium identificationen_US
dc.subjectbacterium isolationen_US
dc.subjectbone tissueen_US
dc.subjectburning sensationen_US
dc.subjectchillen_US
dc.subjectchronic diabetic foot ulceren_US
dc.subjectchronic diabetic foot ulceren_US
dc.subjectchronic diseaseen_US
dc.subjectclinical articleen_US
dc.subjectclinical evaluationen_US
dc.subjectclinical featureen_US
dc.subjectclinical studyen_US
dc.subjectcontrolled studyen_US
dc.subjectCorynebacterium striatumen_US
dc.subjectdebridementen_US
dc.subjectdiabetic footen_US
dc.subjectdizzinessen_US
dc.subjectEscherichia colien_US
dc.subjectfemaleen_US
dc.subjectgangreneen_US
dc.subjectgranulation tissueen_US
dc.subjecthumanen_US
dc.subjecthuman tissueen_US
dc.subjecthypotensionen_US
dc.subjectmaleen_US
dc.subjectmetabolic regulationen_US
dc.subjectMorganella morganiien_US
dc.subjectnauseaen_US
dc.subjectosteomyelitisen_US
dc.subjectpainen_US
dc.subjectperipheral occlusive artery diseaseen_US
dc.subjectProteus mirabilisen_US
dc.subjectPseudomonadalesen_US
dc.subjectPseudomonas aeruginosaen_US
dc.subjectrecurrent peptic ulceren_US
dc.subjectretrospective studyen_US
dc.subjectsepsisen_US
dc.subjectStaphylococcaceaeen_US
dc.subjectsurgical debridementen_US
dc.subjecttreatment indicationen_US
dc.subjecttreatment outcomeen_US
dc.subjecttremoren_US
dc.subjectwound careen_US
dc.subjectwound closureen_US
dc.subjectwound healingen_US
dc.titleThe Effect of Intralesional Human Epidermal Growth Factor on Wound Healing in Chronic Diabetic Foot Ulcer: A Retrospective Analysis of Patient Resultsen_US
dc.title.alternativeKronik Diyabetik Ayak Ülserinde İntralezyonel İnsan Epidermal Büyüme Faktörünün Yara İyileşmesine Etkisi: Hasta Sonuçlarının Retrospektif Analizien_US
dc.typeArticleen_US
dc.identifier.volume32en_US
dc.identifier.issue3en_US
dc.identifier.startpage157en_US
dc.identifier.endpage169en_US
dc.identifier.doi10.5336/dermato.2022-90463-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.authorscopusid57194194375-
dc.authorscopusid42561082000-
dc.identifier.scopus2-s2.0-85144309232en_US
dc.identifier.trdizinid1170319en_US
dc.identifier.scopusqualityQ4-
item.languageiso639-1en-
item.fulltextWith Fulltext-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.01. Surgical Medicine-
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
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