Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/47853
Title: The Effect of Intralesional Human Epidermal Growth Factor on Wound Healing in Chronic Diabetic Foot Ulcer: A Retrospective Analysis of Patient Results
Other Titles: Kronik Diyabetik Ayak Ülserinde İntralezyonel İnsan Epidermal Büyüme Faktörünün Yara İyileşmesine Etkisi: Hasta Sonuçlarının Retrospektif Analizi
Authors: Gökşin, Şule
Çayır, Mustafa Çağdaş
Keywords: adverse effect
culture
diabetic foot
Epidermal growth factor
wound healing
gamma urogastrone
hemoglobin A1c
insulin
oral antidiabetic agent
Acinetobacter baumannii
Acinetobacter calcoaceticus
adult
adverse drug reaction
aged
Article
bacterium culture
bacterium identification
bacterium isolation
bone tissue
burning sensation
chill
chronic diabetic foot ulcer
chronic diabetic foot ulcer
chronic disease
clinical article
clinical evaluation
clinical feature
clinical study
controlled study
Corynebacterium striatum
debridement
diabetic foot
dizziness
Escherichia coli
female
gangrene
granulation tissue
human
human tissue
hypotension
male
metabolic regulation
Morganella morganii
nausea
osteomyelitis
pain
peripheral occlusive artery disease
Proteus mirabilis
Pseudomonadales
Pseudomonas aeruginosa
recurrent peptic ulcer
retrospective study
sepsis
Staphylococcaceae
surgical debridement
treatment indication
treatment outcome
tremor
wound care
wound closure
wound healing
Publisher: OrtadogŸu Reklam Tanitim Yayincilik Turizm Egitim Insaat Sanayi ve Ticaret A.S.
Abstract: Objective: Epidermal growth factor (EGF) plays an important role in wound healing. But, bioavailability of EGF is impaired in chronic diabetic foot ulcer (CDFU) due to increased protease activity. The study's objective was to evaluate the effect of intralesional human-EGF (h-EGF) on wound healing in patients with CDFU. Material and Methods: Twenty-eight patients with CDFU were included to study. 75 µg intralesional h-EGF thrice a week for 5 weeks were used to accelerate wound healing. Ulcer size was calculated by simple planimetric measurement. Specimens for culture were taken from all patients. Granulation response were evaluated with healing grade (HG) [HG-0 ? no response, HG-I ? minimal response, HG-II ? partial response, HG-III ? complete response] and complete wound closure. Pre- and post-treatment ulcers size were recorded to asses treatment outcome. Results: New granulation tissue over the wound (HG I-III) was present in 26 (92.8%) patients at the end of treatment. Complete wound healing (HG III) was achieved in 10 (35.7%) patients, complete wound closure was seen in 3 (10.7%) patients. Pre and post-treatment mean ulcers size were 23.9±18.5 and 6.5±4.8 cm2 (p=0.001). The most frequent adverse events of h-EGF were tremor (32.1%). Total of 47 causative bacterias (14 different types of bacteria) were isolated from 23 (87.2%) patients, whereas cultures were sterile in 5 (17.8%) of the patients. Primarily, Escherichia coli, Proteus mirabilis, Acinetobacter baumannii, Pseudomonas aeruginosa species were seen in rate of 19.1%, 17%, 12.7%, 10.6% respectively. Conclusion: Intralesional h-EGF is effective in the treatment of CDFU, has no serious side-effect and accelerates wound healing. Copyright © 2022 by Türkiye Klinikleri.
URI: https://doi.org/10.5336/dermato.2022-90463
https://hdl.handle.net/11499/47853
ISSN: 1300-0330
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection

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