Low-Grade Tubulopapillary Adenocarcinoma ofSinonasal Tumors: Diagnosis and Follow-up

Abstract

Low grade tubulopapillary adenocarcinoma is one ofthe rare sinonasal tumors. A 65-year-old male patient was admittedto our clinic with painless intraoral and extraoral swelling and speechdisorder. Radiological examination of the patient revealed a lesionsuggesting malignancy. The area of the lesion spread from the leftmaxillary area to the maxillary sinus, nasal cavity, zygomatic boneand the base of the eye, causing resorption of the bones in the regions.As a result of biopsy, the lesion was diagnosed as well-differentiatedlow-grade tubulopapillary adenocarcinoma. The patient was referredto the oncology department of the medical faculty and the radiother apy was started by the medical faculty board, indicating that it was notsuitable for surgical treatment. After 1.5-year follow-up, the patientwas re-biopsied and diagnosed as poorly differentiated tubulopapil lary adenocarcinoma. We think that the aggressive lesion may showheterogeneous differentiation as a possible reason for the differentia tion between the two biopsies.