Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/4867
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dc.contributor.authorGulcelik, M.A.-
dc.contributor.authorDinc, S.-
dc.contributor.authorBir, F.-
dc.contributor.authorElitok, O.-
dc.contributor.authorAlagol, H.-
dc.contributor.authorOz, M.-
dc.date.accessioned2019-08-16T11:38:12Z-
dc.date.available2019-08-16T11:38:12Z-
dc.date.issued2005-
dc.identifier.issn0008-428X-
dc.identifier.urihttps://hdl.handle.net/11499/4867-
dc.description.abstractBackground: Several systemic factors, including jaundice, long-term corticosteroid therapy, diabetes and malnutrition, increase the risk of anastomotic dehiscence. The local application of molgramostim (recombinant human granulocyte-macrophage colony stimulating factor) has been reported to improve impaired dermal wound healing. Since jaundice, one of the systemic risk factors for anastomotic dehiscence, causes significant impairment of anastomotic healing, we hypothesized that locally injected molgramostim could improve the healing of bowel anastomoses in bile-duct-ligated rats used as an experimental model for jaundice. Methods: Eighty-six Sprague-Dawley rats were randomized into 4 groups of 20-22 animals each as follows: group 1 - colonic anastomosis only; group 2 - laparotomy followed 7 days later by colonic anastomosis; group 3 - common-bile-duct ligation (CBDL) followed 7 days later by colonic anastomosis (control group); group 4 - CBDL followed by colonic anastomosis with locally applied molgramostim. Laparotomy was performed under anesthesia in group 2 rats. In groups 3 and 4, laparotomy was followed by ligation and dissection of the common bile duct. After 7 days, colonic anastomosis was performed; in group 4 rats, molgramostim (50 µg) was injected into the perianastomotic area. On postoperative day 3, rats were killed, and the bursting pressures and hydroxy-proline levels measured. Two rats from each group were selected for histopathological examination. Results: The mean bursting pressure in group 4 was significantly higher than that in group 3 (37.8 v. 30.5 mm Hg [p < 0.01]). The mean hydroxyproline level in group 3 was significantly lower than that of the other groups (2.7 v. 3.1-3.5 mg/g tissue [p < 0.01]). On histopathological examination, specimens from group 4 rats showed an increased mononuclear cell population and a smaller gap on the anastomotic line than, those from group 3. Conclusion: The local injection of molgramostim improves healing of the impaired wound in rats subjected to CBDL. © 2005 CMA Media Inc.en_US
dc.language.isoenen_US
dc.relation.ispartofCanadian Journal of Surgeryen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjecthydroxyprolineen_US
dc.subjectketamineen_US
dc.subjectrecombinant granulocyte macrophage colony stimulating factoren_US
dc.subjectxylazineen_US
dc.subjectanimal experimenten_US
dc.subjectanimal tissueen_US
dc.subjectarticleen_US
dc.subjectbiliary tract surgeryen_US
dc.subjectcell populationen_US
dc.subjectcolon anastomosisen_US
dc.subjectcommon bile ducten_US
dc.subjectcontrolled studyen_US
dc.subjectcorticosteroid therapyen_US
dc.subjectdiabetes mellitusen_US
dc.subjecthistopathologyen_US
dc.subjectjaundiceen_US
dc.subjectlaparotomyen_US
dc.subjectmaleen_US
dc.subjectmalnutritionen_US
dc.subjectmononuclear cellen_US
dc.subjectnonhumanen_US
dc.subjectraten_US
dc.subjectwound dehiscenceen_US
dc.subjectwound healingen_US
dc.subjectAdministration, Topicalen_US
dc.subjectAnastomosis, Surgicalen_US
dc.subjectAnimalsen_US
dc.subjectColonen_US
dc.subjectCommon Bile Ducten_US
dc.subjectGranulocyte-Macrophage Colony-Stimulating Factoren_US
dc.subjectHydroxyprolineen_US
dc.subjectLigationen_US
dc.subjectMaleen_US
dc.subjectPressureen_US
dc.subjectRatsen_US
dc.subjectRats, Sprague-Dawleyen_US
dc.subjectRecombinant Proteinsen_US
dc.subjectStress, Mechanicalen_US
dc.subjectWound Healingen_US
dc.titleLocally applied molgramostim improves wound healing at colonic anastomoses in rats after ligation of the common bile ducten_US
dc.typeArticleen_US
dc.identifier.volume48en_US
dc.identifier.issue3en_US
dc.identifier.startpage213
dc.identifier.startpage213en_US
dc.identifier.endpage218en_US
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid16013625en_US
dc.identifier.scopus2-s2.0-21344457934en_US
dc.identifier.wosWOS:000229637600007en_US
dc.identifier.scopusqualityQ2-
dc.ownerPamukkale_University-
item.languageiso639-1en-
item.fulltextWith Fulltext-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.dept14.01. Surgical Medicine-
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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