Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/50421
Full metadata record
DC Field | Value | Language |
---|---|---|
dc.contributor.author | Alpan, A. Lektemur | - |
dc.contributor.author | Cin, G. Torumtay | - |
dc.contributor.author | Özmen, O. | - |
dc.contributor.author | Doğan, M. F. | - |
dc.contributor.author | Şahin, Y. | - |
dc.date.accessioned | 2023-04-08T09:58:31Z | - |
dc.date.available | 2023-04-08T09:58:31Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 0022-0930 | - |
dc.identifier.issn | 1608-3202 | - |
dc.identifier.uri | https://doi.org/10.1134/S0022093022020119 | - |
dc.identifier.uri | https://hdl.handle.net/11499/50421 | - |
dc.description.abstract | Introduction: Favipiravir and Vitamin C (Vit C) were used together in the treatment of the COVID-19 pandemic. However, the effects of favipiravir on the periodontium are still unknown. Therefore, the aim of this study was to investigate the effects of Favipiravir and Vit C treatment on alveolar bone metabolism. Experimental: Fifty healthy adult male Sprague-Dawley rats (2-3 months old) were randomly divided into five equal groups (n = 10): Control, Favi 20, Favi 100, Favi 20+Vit C, Favi 100+Vit C. Favipiravir (20 mg/kg and 100 mg/kg, i.m.) and Vit C (150 mg/kg/day, oral) were administered to the rats for 14 days. Alveolar bone loss (ABL) and histopathological changes were examined using a light microscope. Immunohistochemistry was used to determine levels of receptor activator of nuclear factor kappa-B ligand (RANKL), caspase-3, bone morphogenic protein 2 (BMP-2) and alkaline phosphaTaşe (ALP) in the bone tissues. Results: Favipiravir increased the levels of RANKL and caspase-3 expression but decreased BMP-2 and ALP levels in a dose-dependent manner. Favi 20+Vit C and Favi 100 +Vit C groups showed decreased RANKL and caspase-3 levels in addition to increased BMP-2 and ALP levels. Conclusion: Favipiravir can cause histopathological damage to the periodontium, but administration of favipiravir combined with Vit C can provide a protective effect against this damage. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Pleiades Publishing Inc | en_US |
dc.relation.ispartof | Journal of Evolutionary Biochemistry and Physiology | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Alveolar bone loss | en_US |
dc.subject | bone formation | en_US |
dc.subject | Favipiravir | en_US |
dc.subject | Vitamin C | en_US |
dc.subject | RANKL | en_US |
dc.subject | BMP-2 | en_US |
dc.subject | Caspase-3 | en_US |
dc.subject | Mineral Density | en_US |
dc.subject | Alkaline-PhosphaTaşe | en_US |
dc.subject | Antiviral Activity | en_US |
dc.subject | Ascorbic-Acid | en_US |
dc.subject | Differentiation | en_US |
dc.subject | Protection | en_US |
dc.subject | Caspase-3 | en_US |
dc.subject | Tenofovir | en_US |
dc.subject | Virus | en_US |
dc.subject | T-705 | en_US |
dc.title | Evaluation of the Effects of Favipiravir Combined with Vitamin C on Alveolar Bone in Rats | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 58 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 430 | en_US |
dc.identifier.endpage | 440 | en_US |
dc.department | Pamukkale University | en_US |
dc.identifier.doi | 10.1134/S0022093022020119 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 35599639 | en_US |
dc.identifier.wos | WOS:000796544500011 | en_US |
dc.institutionauthor | … | - |
dc.identifier.scopusquality | Q4 | - |
item.fulltext | With Fulltext | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
item.cerifentitytype | Publications | - |
item.openairetype | Article | - |
crisitem.author.dept | 06.01. Clinical Sciences | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
Appears in Collections: | Diş Hekimliği Fakültesi Koleksiyonu PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Files in This Item:
File | Size | Format | |
---|---|---|---|
S0022093022020119.pdf | 1.31 MB | Adobe PDF | View/Open |
CORE Recommender
WEB OF SCIENCETM
Citations
5
checked on Oct 31, 2024
Page view(s)
58
checked on Aug 24, 2024
Download(s)
20
checked on Aug 24, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.