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https://hdl.handle.net/11499/50421
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DC Field | Value | Language |
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dc.contributor.author | Alpan, A. Lektemur | - |
dc.contributor.author | Cin, G. Torumtay | - |
dc.contributor.author | Özmen, O. | - |
dc.contributor.author | Doğan, M. F. | - |
dc.contributor.author | Şahin, Y. | - |
dc.date.accessioned | 2023-04-08T09:58:31Z | - |
dc.date.available | 2023-04-08T09:58:31Z | - |
dc.date.issued | 2022 | - |
dc.identifier.issn | 0022-0930 | - |
dc.identifier.issn | 1608-3202 | - |
dc.identifier.uri | https://doi.org/10.1134/S0022093022020119 | - |
dc.identifier.uri | https://hdl.handle.net/11499/50421 | - |
dc.description.abstract | Introduction: Favipiravir and Vitamin C (Vit C) were used together in the treatment of the COVID-19 pandemic. However, the effects of favipiravir on the periodontium are still unknown. Therefore, the aim of this study was to investigate the effects of Favipiravir and Vit C treatment on alveolar bone metabolism. Experimental: Fifty healthy adult male Sprague-Dawley rats (2-3 months old) were randomly divided into five equal groups (n = 10): Control, Favi 20, Favi 100, Favi 20+Vit C, Favi 100+Vit C. Favipiravir (20 mg/kg and 100 mg/kg, i.m.) and Vit C (150 mg/kg/day, oral) were administered to the rats for 14 days. Alveolar bone loss (ABL) and histopathological changes were examined using a light microscope. Immunohistochemistry was used to determine levels of receptor activator of nuclear factor kappa-B ligand (RANKL), caspase-3, bone morphogenic protein 2 (BMP-2) and alkaline phosphaTaşe (ALP) in the bone tissues. Results: Favipiravir increased the levels of RANKL and caspase-3 expression but decreased BMP-2 and ALP levels in a dose-dependent manner. Favi 20+Vit C and Favi 100 +Vit C groups showed decreased RANKL and caspase-3 levels in addition to increased BMP-2 and ALP levels. Conclusion: Favipiravir can cause histopathological damage to the periodontium, but administration of favipiravir combined with Vit C can provide a protective effect against this damage. | en_US |
dc.language.iso | en | en_US |
dc.publisher | Pleiades Publishing Inc | en_US |
dc.relation.ispartof | Journal of Evolutionary Biochemistry and Physiology | en_US |
dc.rights | info:eu-repo/semantics/openAccess | en_US |
dc.subject | Alveolar bone loss | en_US |
dc.subject | bone formation | en_US |
dc.subject | Favipiravir | en_US |
dc.subject | Vitamin C | en_US |
dc.subject | RANKL | en_US |
dc.subject | BMP-2 | en_US |
dc.subject | Caspase-3 | en_US |
dc.subject | Mineral Density | en_US |
dc.subject | Alkaline-PhosphaTaşe | en_US |
dc.subject | Antiviral Activity | en_US |
dc.subject | Ascorbic-Acid | en_US |
dc.subject | Differentiation | en_US |
dc.subject | Protection | en_US |
dc.subject | Caspase-3 | en_US |
dc.subject | Tenofovir | en_US |
dc.subject | Virus | en_US |
dc.subject | T-705 | en_US |
dc.title | Evaluation of the Effects of Favipiravir Combined with Vitamin C on Alveolar Bone in Rats | en_US |
dc.type | Article | en_US |
dc.identifier.volume | 58 | en_US |
dc.identifier.issue | 2 | en_US |
dc.identifier.startpage | 430 | en_US |
dc.identifier.endpage | 440 | en_US |
dc.department | Pamukkale University | en_US |
dc.identifier.doi | 10.1134/S0022093022020119 | - |
dc.relation.publicationcategory | Makale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanı | en_US |
dc.identifier.pmid | 35599639 | en_US |
dc.identifier.wos | WOS:000796544500011 | en_US |
dc.institutionauthor | … | - |
dc.identifier.scopusquality | Q4 | - |
item.openairecristype | http://purl.org/coar/resource_type/c_18cf | - |
item.openairetype | Article | - |
item.cerifentitytype | Publications | - |
item.fulltext | With Fulltext | - |
item.grantfulltext | open | - |
item.languageiso639-1 | en | - |
crisitem.author.dept | 06.01. Clinical Sciences | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
crisitem.author.dept | 14.02. Internal Medicine | - |
Appears in Collections: | Diş Hekimliği Fakültesi Koleksiyonu PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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File | Size | Format | |
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S0022093022020119.pdf | 1.31 MB | Adobe PDF | View/Open |
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