Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/50421
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dc.contributor.authorAlpan, A. Lektemur-
dc.contributor.authorCin, G. Torumtay-
dc.contributor.authorÖzmen, O.-
dc.contributor.authorDoğan, M. F.-
dc.contributor.authorŞahin, Y.-
dc.date.accessioned2023-04-08T09:58:31Z-
dc.date.available2023-04-08T09:58:31Z-
dc.date.issued2022-
dc.identifier.issn0022-0930-
dc.identifier.issn1608-3202-
dc.identifier.urihttps://doi.org/10.1134/S0022093022020119-
dc.identifier.urihttps://hdl.handle.net/11499/50421-
dc.description.abstractIntroduction: Favipiravir and Vitamin C (Vit C) were used together in the treatment of the COVID-19 pandemic. However, the effects of favipiravir on the periodontium are still unknown. Therefore, the aim of this study was to investigate the effects of Favipiravir and Vit C treatment on alveolar bone metabolism. Experimental: Fifty healthy adult male Sprague-Dawley rats (2-3 months old) were randomly divided into five equal groups (n = 10): Control, Favi 20, Favi 100, Favi 20+Vit C, Favi 100+Vit C. Favipiravir (20 mg/kg and 100 mg/kg, i.m.) and Vit C (150 mg/kg/day, oral) were administered to the rats for 14 days. Alveolar bone loss (ABL) and histopathological changes were examined using a light microscope. Immunohistochemistry was used to determine levels of receptor activator of nuclear factor kappa-B ligand (RANKL), caspase-3, bone morphogenic protein 2 (BMP-2) and alkaline phosphaTaşe (ALP) in the bone tissues. Results: Favipiravir increased the levels of RANKL and caspase-3 expression but decreased BMP-2 and ALP levels in a dose-dependent manner. Favi 20+Vit C and Favi 100 +Vit C groups showed decreased RANKL and caspase-3 levels in addition to increased BMP-2 and ALP levels. Conclusion: Favipiravir can cause histopathological damage to the periodontium, but administration of favipiravir combined with Vit C can provide a protective effect against this damage.en_US
dc.language.isoenen_US
dc.publisherPleiades Publishing Incen_US
dc.relation.ispartofJournal of Evolutionary Biochemistry and Physiologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectAlveolar bone lossen_US
dc.subjectbone formationen_US
dc.subjectFavipiraviren_US
dc.subjectVitamin Cen_US
dc.subjectRANKLen_US
dc.subjectBMP-2en_US
dc.subjectCaspase-3en_US
dc.subjectMineral Densityen_US
dc.subjectAlkaline-PhosphaTaşeen_US
dc.subjectAntiviral Activityen_US
dc.subjectAscorbic-Aciden_US
dc.subjectDifferentiationen_US
dc.subjectProtectionen_US
dc.subjectCaspase-3en_US
dc.subjectTenofoviren_US
dc.subjectVirusen_US
dc.subjectT-705en_US
dc.titleEvaluation of the Effects of Favipiravir Combined with Vitamin C on Alveolar Bone in Ratsen_US
dc.typeArticleen_US
dc.identifier.volume58en_US
dc.identifier.issue2en_US
dc.identifier.startpage430en_US
dc.identifier.endpage440en_US
dc.departmentPamukkale Universityen_US
dc.identifier.doi10.1134/S0022093022020119-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.pmid35599639en_US
dc.identifier.wosWOS:000796544500011en_US
dc.institutionauthor-
dc.identifier.scopusqualityQ4-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.openairetypeArticle-
item.cerifentitytypePublications-
item.fulltextWith Fulltext-
item.grantfulltextopen-
item.languageiso639-1en-
crisitem.author.dept06.01. Clinical Sciences-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.02. Internal Medicine-
Appears in Collections:Diş Hekimliği Fakültesi Koleksiyonu
PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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