Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/50462
Title: Exploring Mitomirs in Breast Cancer: An In-Vitro Study of Their Emerging Roles
Authors: Tokgun, Pervin Elvan
Tomatir, Ayşe Gaye
Keywords: mitomiRs
MACS
breast cancer
small RNA sequenc-ing
Mitochondria
Localization
Micrornas
Publisher: Istanbul Univ, Fac Medicine, Publ Off
Abstract: Objective: Breast cancer is associated with a 5% genetic predisposition in women. Mitochondria play a role in important cellular events such as metabolism, cell death, and inflammation. Recent studies have highlighted precursor micro-RNA (pre-miRNA) to be located in mitochondria as well as mature miRNA. This study aims to reveal the occurrence of mitochondrial miRNA (mitomiR) in breast cancer cells.Materials and Methods: The study has prepared the mitochondrial fractions using the magnetic-activated cell sorting (MACS) method and performed small RNA (sRNA) sequencing.Results: The study has identified known and novel mitomiR sequences aligned to the mitochondrial genome.Conclusion: Identifying new mitomiRs can provide significant contributions and illuminate the molecular mechanism underlying mitomiR biogenesis.
Description: Article; Early Access
URI: https://doi.org/10.26650/IUITFD.1200910
https://hdl.handle.net/11499/50462
ISSN: 1305-6441
Appears in Collections:Sağlık Araştırma ve Uygulama Merkezi Koleksiyonu
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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