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https://hdl.handle.net/11499/51247
Title: | The anticancer effect of Salvia pisidica essential oil through promotion intrinsic and extrinsic apoptosis pathways in human cancer cell lines | Authors: | Semiz, Gürkan Mutlu, D. Günal, Batıkan Semiz, Aslı Arslan, Şevki |
Keywords: | Apoptotic Cytotoxic Essential oil GC-MS Salvia pisidica 4 cymene 7 ol absinthol alpha cubebene alpha gualene alpha gurjunene aromadendrene beta humulene beta pinene borneol cadalene camphene camphor carvacrol carveol carvone caryaphyllene oxide cineole copaene cuminaldehyde delta cadinene essential oil eugenol gamma cadinene gamma elemene gamma gurjunene jasmone limonene lipocortin 5 longifolene mycene myrtenol ocimene phellendral pinene pinocarvone piperitone plant medicinal product terpenoid derivative terpinene terpineol unclassified drug verbenone viridiflorol antineoplastic activity antitumorigenic activity apoptosis Article breast cancer cell line Caco-2 cell line cancer cell line chemical composition colon carcinoma cell line controlled study cytotoxicity drug determination embryo HEK293 cell line hepatocellular carcinoma cell line human human cell image cytometry in vitro study intrinsic activity LNCaP cell line mass fragmentography MCF-7 cell line MTT assay prostate carcinoma cell line real time polymerase chain reaction Salvia Salvia pisidica |
Publisher: | Elsevier GmbH | Abstract: | Introduction: Species of the Salvia genus are aromatic herbs and traditionally used for many medicinal purposes in Anatolia. The genus has produced an extraordinarily large number of beneficial secondary metabolites belonging to numerous chemical groups. Salvia pisidica is an endemic plant of southwest Anatolia, the dried parts of which are used as herbal tea and local materia medica. Methods: The composition of endemic S. pisidica essential oil was determined through GC-MS studies. In vitro cytotoxicity activity and apoptosis analysis were investigated by MTT assay, q-PCR and Annexin V staining experiments. Results: Our results showed that 1,8 cineole (19.15 %) camphor (18.12 %) and γ-gurjunene (8.58 %) were the major constituents of the essential oil. It showed cytotoxic effects on the human breast cancer MCF-7, colon carcinoma Caco-2, hepatocyte carcinoma HepG2, and prostate carcinoma LnCap. The results of q-PCR and image-cytometer analysis showed that the essential oil caused induction of apoptosis by intrinsic and extrinsic pathways in all cancer cell lines. Conclusion: S. pisidica essential oil demonstrates considerable cytotoxic activity due to an apoptosis-related mechanism, suggesting that their bioactive components could be used as natural anticancer substances. © 2023 Elsevier GmbH | URI: | https://doi.org/10.1016/j.hermed.2023.100664 https://hdl.handle.net/11499/51247 |
ISSN: | 2210-8033 |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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