Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/51247
Title: The anticancer effect of Salvia pisidica essential oil through promotion intrinsic and extrinsic apoptosis pathways in human cancer cell lines
Authors: Semiz, Gürkan
Mutlu, D.
Günal, Batıkan
Semiz, Aslı
Arslan, Şevki
Keywords: Apoptotic
Cytotoxic
Essential oil
GC-MS
Salvia pisidica
4 cymene 7 ol
absinthol
alpha cubebene
alpha gualene
alpha gurjunene
aromadendrene
beta humulene
beta pinene
borneol
cadalene
camphene
camphor
carvacrol
carveol
carvone
caryaphyllene oxide
cineole
copaene
cuminaldehyde
delta cadinene
essential oil
eugenol
gamma cadinene
gamma elemene
gamma gurjunene
jasmone
limonene
lipocortin 5
longifolene
mycene
myrtenol
ocimene
phellendral
pinene
pinocarvone
piperitone
plant medicinal product
terpenoid derivative
terpinene
terpineol
unclassified drug
verbenone
viridiflorol
antineoplastic activity
antitumorigenic activity
apoptosis
Article
breast cancer cell line
Caco-2 cell line
cancer cell line
chemical composition
colon carcinoma cell line
controlled study
cytotoxicity
drug determination
embryo
HEK293 cell line
hepatocellular carcinoma cell line
human
human cell
image cytometry
in vitro study
intrinsic activity
LNCaP cell line
mass fragmentography
MCF-7 cell line
MTT assay
prostate carcinoma cell line
real time polymerase chain reaction
Salvia
Salvia pisidica
Publisher: Elsevier GmbH
Abstract: Introduction: Species of the Salvia genus are aromatic herbs and traditionally used for many medicinal purposes in Anatolia. The genus has produced an extraordinarily large number of beneficial secondary metabolites belonging to numerous chemical groups. Salvia pisidica is an endemic plant of southwest Anatolia, the dried parts of which are used as herbal tea and local materia medica. Methods: The composition of endemic S. pisidica essential oil was determined through GC-MS studies. In vitro cytotoxicity activity and apoptosis analysis were investigated by MTT assay, q-PCR and Annexin V staining experiments. Results: Our results showed that 1,8 cineole (19.15 %) camphor (18.12 %) and γ-gurjunene (8.58 %) were the major constituents of the essential oil. It showed cytotoxic effects on the human breast cancer MCF-7, colon carcinoma Caco-2, hepatocyte carcinoma HepG2, and prostate carcinoma LnCap. The results of q-PCR and image-cytometer analysis showed that the essential oil caused induction of apoptosis by intrinsic and extrinsic pathways in all cancer cell lines. Conclusion: S. pisidica essential oil demonstrates considerable cytotoxic activity due to an apoptosis-related mechanism, suggesting that their bioactive components could be used as natural anticancer substances. © 2023 Elsevier GmbH
URI: https://doi.org/10.1016/j.hermed.2023.100664
https://hdl.handle.net/11499/51247
ISSN: 2210-8033
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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