Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/51500
Title: The Optimal Treatment Approaches and Prognostic Factors in Elderly Patients with Advanced Stage Biliary Tract Tumors
Authors: Göktaş Aydın, Sabin
Çakan Demirel, Burçin
Bilici, Ahmet
Yılmaz, Cansu
Topçu, Atakan
Aykan, Musa Barış
Kahraman, Seda
Atçı, Muhammed Mustafa
Akbıyık, Ilgın
Akgül, Fahri
Ölmez, Ömer Fatih
Aydın, Ahmet
Abstract: Introduction: There is a lack of evidence of the outcomes in elderly patients advanced stage biliary tract cancer due to the patients aged over 65 years are less than 25% in many prospective trials. We designed a retrospective multicenter study to evaluate the factors affecting treatment and survival in elderly patients with advanced-stage biliary tract cancer. Materials and methods: A total of 116 patients with advanced stage biliary tract cancer aged ≥65 years were included, and the treatment responses, survival, and toxicity rates were evaluated with respect to age groups Results: There was no significant difference between age and response to treatment, survival, or toxicity. The median progression-free survival and overall survival were 5.3, and 11.8 months respectively. Multivariate analysis indicated that ECOG PS (p<0.001 CI95% 1.5-3.7) and PNI (p<0.001 CI 95% 0.14-0.41) were significant independent prognostic factors for PFS. The independent prognostic factors for OS were choice of frontline regimen, NLR and PNI (p=0.007 CI 95% 0.71 – 0.94, p=0.006 CI 95% 1.2 – 3.1, p=0.001 CI 95% 0.35 – 0.91, respectively). Discussion: This study confirms the general prognostic relevance of inflammatory parameters and the importance of frontline treatment in elderly patients with advanced-stage biliary tract tumors. Additionally, getting older does not indicate that treatment will be avoided or that they will have a worse prognosis and suffer from more toxicities.
URI: https://doi.org/10.5505/aot.2023.03708
https://search.trdizin.gov.tr/yayin/detay/1177946
https://hdl.handle.net/11499/51500
ISSN: 0304-596X
2148-7669
Appears in Collections:Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection

Files in This Item:
File SizeFormat 
document - 2024-04-18T144240.374.pdf389.27 kBAdobe PDFView/Open
Show full item record



CORE Recommender

Page view(s)

56
checked on Aug 24, 2024

Download(s)

14
checked on Aug 24, 2024

Google ScholarTM

Check




Altmetric


Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.