Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5265
Title: Emergence of phenotypic resistance to ciprofloxacin and levofloxacin in methicillin-resistant and methicillin-sensitive Staphylococcus aureus strains
Authors: Limoncu, M.H.
Ermertcan, S.
Çetin, Çiğdem Banu
Cosar, G.
Dinç, G.
Keywords: Ciprofloxacin
Levofloxacin
Phenotypic resistance
Staphylococcus aureus
ciprofloxacin
levofloxacin
quinoline derived antiinfective agent
antibiotic resistance
antibiotic sensitivity
article
bacterial growth
bacterial strain
bacterium culture
concentration response
controlled study
incubation time
methicillin resistant Staphylococcus aureus
minimum inhibitory concentration
nonhuman
phenotype
priority journal
Publisher: Elsevier
Abstract: The emergence of phenotypic resistance to ciprofloxacin and levofloxacin in methicillin-sensitive and methicillin-resistant Staphylococcus aureus (MRSA) strains was studied. Twenty MRSA and 77 methicillin-sensitive S.aureus (MSSA) strains susceptible to both quinolones were investigated for resistance after single step or serial passages. No growth of 20 MRSA strains was observed at 4×MIC of levofloxacin after 48 h incubation, but 4 of 77 (5%) MSSA strains grew at the same concentration. At 4×MIC concentration of ciprofloxacin, 10 MSSA (13%) and five MRSA (25%) strains were grown. In the serial passages of MRSA strains, resistance to ciprofloxacin was 75 and 5% for levofloxacin by the third passage. In the seventh passage this resistance was 100 and 15%, respectively. In MSSA strains, resistance to ciprofloxacin was 75 and 19% to levofloxacin at the third passage and at the seventh passage, 100 and 61%, respectively. Emergence of ciprofloxacin resistance was more common and developed more rapidly than resistance to levofloxacin in both MRSA and MSSA strains. © 2003 Elsevier Science B.V. and the International Society of Chemotherapy. All rights reserved.
URI: https://hdl.handle.net/11499/5265
https://doi.org/10.1016/S0924-8579(03)00006-2
ISSN: 0924-8579
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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