Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5322
Title: Effect of ?-tocopherol on lipid peroxidation caused by cisplatin in rat kidney
Authors: Bolaman, Z.
Köseo?lu, M.H.
Demir, S.
Kadiköylü, G.
Barutca, S.
Atalay, H.
Aslan, D.
Keywords: ?-Tocopherol
Cisplatin
Malondialdehyde
alpha tocopherol
cisplatin
cisplatinum onko
lipid
malonaldehyde
sodium chloride
animal experiment
animal model
animal tissue
article
calculation
cancer
controlled study
diet restriction
disease association
drug antagonism
drug effect
drug induced disease
kidney
lipid peroxidation
male
nephrotoxicity
nonhuman
rat
urine level
Abstract: Cisplatin (CDDP) is one of the most commonly used antineoplastic agents in current clinical practice. The major toxicities of CDDP are nonhaematological as nephrotoxicity and ototoxicity. Free oxygen radicals are known to play major role in CDDP-induced acute renal failure in rats. ?-Tocopherol is one of the well-known antioxidant agents. This study was designed to investigate the role of ?-tocopherol pretreatment against CDDP-induced lipid peroxidation in rat kidney. Male Wistar rats were divided into three groups and treated as follows: control (saline intraperitoneally), CDDP (10 mg/kg, intraperitoneally), ?-tocopherol (200 mg/kg, plus CDDP, intraperitoneally). Rats were sacrificed on third day of the treatment, and kidney tissues were obtained and analyzed. CDDP-treated rats showed high malondialdehyde (MDA) levels (p< 0.05). In the CDDP plus ?-tocopherol group, renal MDA levels were not significantly different from the controls. These data suggest that ?-tocopherol may be used to prevent CDDP-induced lipid peroxidation.
URI: https://hdl.handle.net/11499/5322
ISSN: 1300-7777
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu

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