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https://hdl.handle.net/11499/5322
Title: | Effect of ?-tocopherol on lipid peroxidation caused by cisplatin in rat kidney | Authors: | Bolaman, Z. Köseo?lu, M.H. Demir, S. Kadiköylü, G. Barutca, S. Atalay, H. Aslan, D. |
Keywords: | ?-Tocopherol Cisplatin Malondialdehyde alpha tocopherol cisplatin cisplatinum onko lipid malonaldehyde sodium chloride animal experiment animal model animal tissue article calculation cancer controlled study diet restriction disease association drug antagonism drug effect drug induced disease kidney lipid peroxidation male nephrotoxicity nonhuman rat urine level |
Abstract: | Cisplatin (CDDP) is one of the most commonly used antineoplastic agents in current clinical practice. The major toxicities of CDDP are nonhaematological as nephrotoxicity and ototoxicity. Free oxygen radicals are known to play major role in CDDP-induced acute renal failure in rats. ?-Tocopherol is one of the well-known antioxidant agents. This study was designed to investigate the role of ?-tocopherol pretreatment against CDDP-induced lipid peroxidation in rat kidney. Male Wistar rats were divided into three groups and treated as follows: control (saline intraperitoneally), CDDP (10 mg/kg, intraperitoneally), ?-tocopherol (200 mg/kg, plus CDDP, intraperitoneally). Rats were sacrificed on third day of the treatment, and kidney tissues were obtained and analyzed. CDDP-treated rats showed high malondialdehyde (MDA) levels (p< 0.05). In the CDDP plus ?-tocopherol group, renal MDA levels were not significantly different from the controls. These data suggest that ?-tocopherol may be used to prevent CDDP-induced lipid peroxidation. | URI: | https://hdl.handle.net/11499/5322 | ISSN: | 1300-7777 |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu |
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