Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/54955
Title: Analysis of Risk Factors Associated with Candidemia Among Patients with or without COVID-19 in Intensive Care Units During the Pandemic Process: A Multicenter Study
Authors: Karakok, Taliha
Gözükara, Melih Gaffar
Uygun Kızmaz, Yeşim
Demir, Yakup
Toruyenler Coşkunpınar, Melike
Altun Demircan, Şerife
Arslan, Yusuf
İlkören, Pelin
Alp Göker, Eda
Doğan, Ahmet
Tüzün, Türkan
Sevim, Şükran
Çakır, Yasemin
Işık, Mehmet Emirhan
Mermutoğlu, Çiğdem
Azap, Alpay
Kınıklı, Sami
Tekin, Süda
Şimşek Yavuz, Serap
Öner, Sedef Zeliha
Keywords: Candidemia
COVID-19
Risk factors
Intensive care unit
Publisher: Bilimsel Tip Yayinevi
Abstract: Introduction: The objective of this study was to compare the risk factors and mortality rates of candidemia among patients with and without COVID-19 in the intensive care units (ICU).Materials and Methods: This study is a retrospective multicenter observational study, in ICUs of 12 hospitals (eight tertiary and four secondary hospitals) in Tarkiye. All adult patients (>18 years) hospitalized in ICUs and developed candidemia between 01.01.2020-31.12.2021 were included. The following data were collected: age, gender, nasopharyngeal swab SARS-CoV-2 PCR test, species of Candida (Candida albicans or non-albicans Candida), comorbidities, ICU stay, antibiotic use, corticosteroid, and anti-cytokine therapy, central venous catheter (CVC), abdominal surgery, parenteral nutrition, mechanical ventilation (MV), other cultures isolated Candida spp., echocardiography (ECO), mortality. Data from patients with or without COVID-19 were compared.Results: A total of 188 patients, 66 COVID-19 and 122 non-COVID-19, were included in the study. The median age of the patients was 69.5 and there were no differences between the groups. 185 (98.4%) patients had a history of antibiotic use. Sixteen patients, all from the COVID-19 group, had a history of anti-cytokine therapy. Corticosteroid use was higher in COVID-19 patients (p< 0.001). Intraabdominal surgery was higher in the non-COVID-19 group (p< 0.014). C. albicans was isolated from 36.7% of total patients and the remaining were non-albicans Candida species. The overall mortality was higher in COVID-19 patients (p= 0.014). Alzheimer's and malignancies were higher in non-COVID-19 patients. Intraabdominal surgery, MV, and CVC were higher in tertiary care hospitals whereas parenteral nutrition was higher in secondary care hospitals.Conclusion: Immunosuppressive treatments administered to COVID-19 patients pose a risk in terms of candidemia. Risk factors may differ between secondary and tertiary care hospitals. Preventable risk factors should be determined on a hospital basis and appropriate infection control measures should be taken.
URI: https://doi.org/10.5578/flora.20239716
https://hdl.handle.net/11499/54955
ISSN: 1300-932X
2602-2842
Appears in Collections:Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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