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Title: | Destruction of the noradrenergic system with DSP4 potentiates the behavioral effects of MK-801 in rats | Authors: | Hatip-Al-Khatib, İzzettin Bölükbaşı, Funda |
Keywords: | Ataxia DSP4 Hyperlocomotor activity MK-801 Noradrenaline Rat Stereotypy 2 bromo n (2 chloroethyl) n ethylbenzylamine dizocilpine animal experiment article ataxia behavior circling behavior controlled study intraperitoneal drug administration locomotion male nonhuman noradrenergic system priority journal rat rearing stereotypy Adrenergic Agents Animals Behavior, Animal Benzylamines Dizocilpine Maleate Drug Synergism Excitatory Amino Acid Antagonists Male Motor Activity Rats Rats, Wistar Stereotyped Behavior |
Abstract: | In this study we investigated the effect of lesioning the noradrenergic systems on the behavioral effects of (5R, 10S)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5,10-imine hydrogen maleate-MK-801, in rats. The noradrenergic system was lesioned with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride-DSP4 (60 mg/kg IP). MK-801 increased the locomotor activity and rearing. DSP4 significantly further increased the hyperlocomotor activity, circling (especially to the left side), sniffing, rolling, and falling that were induced by MK-801. These results showed that destruction of the noradrenergic system increased MK-801-hyperlocomotor activity, ataxia and stereotypy. Copyright (C) 1999 Elsevier Science Inc. | URI: | https://hdl.handle.net/11499/5598 https://doi.org/10.1016/S0091-3057(98)00169-5 |
ISSN: | 0091-3057 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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