Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5598
Title: Destruction of the noradrenergic system with DSP4 potentiates the behavioral effects of MK-801 in rats
Authors: Hatip-Al-Khatib, İzzettin
Bölükbaşı, Funda
Keywords: Ataxia
DSP4
Hyperlocomotor activity
MK-801
Noradrenaline
Rat
Stereotypy
2 bromo n (2 chloroethyl) n ethylbenzylamine
dizocilpine
animal experiment
article
ataxia
behavior
circling behavior
controlled study
intraperitoneal drug administration
locomotion
male
nonhuman
noradrenergic system
priority journal
rat
rearing
stereotypy
Adrenergic Agents
Animals
Behavior, Animal
Benzylamines
Dizocilpine Maleate
Drug Synergism
Excitatory Amino Acid Antagonists
Male
Motor Activity
Rats
Rats, Wistar
Stereotyped Behavior
Abstract: In this study we investigated the effect of lesioning the noradrenergic systems on the behavioral effects of (5R, 10S)-(+)-5-Methyl-10,11-dihydro-5H-dibenzo [a, d] cyclohepten-5,10-imine hydrogen maleate-MK-801, in rats. The noradrenergic system was lesioned with N-(2-chloroethyl)-N-ethyl-2-bromobenzylamine hydrochloride-DSP4 (60 mg/kg IP). MK-801 increased the locomotor activity and rearing. DSP4 significantly further increased the hyperlocomotor activity, circling (especially to the left side), sniffing, rolling, and falling that were induced by MK-801. These results showed that destruction of the noradrenergic system increased MK-801-hyperlocomotor activity, ataxia and stereotypy. Copyright (C) 1999 Elsevier Science Inc.
URI: https://hdl.handle.net/11499/5598
https://doi.org/10.1016/S0091-3057(98)00169-5
ISSN: 0091-3057
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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