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https://hdl.handle.net/11499/5611| Title: | Preventive effect of ticlopidine on postoperative thrombus formation after experimental microsurgical carotid endarterectomy in rats | Authors: | Suzer, T. Tahta, K. Celik, H. Ozcan, O.E. |
Keywords: | Carotid endarterectomy Microneurosurgery Postoperative thrombosis Scanning electron microscopy Thrombus formation Ticlopidine ticlopidine animal experiment animal model animal tissue aorta injury article carotid endarterectomy controlled study microsurgery nonhuman oral drug administration postoperative complication rat scanning electron microscopy thrombocyte aggregation thrombosis |
Publisher: | Turkish Neurosurgical Society | Abstract: | The purpose of this study was to investigate the preventive effect of Ticlopidine on thrombus formation after surgical arterial injury. The model of microsurgical carotid endarterectomy was performed on the common carotid arteries in rats. Twenty rats were equally divided into two groups: a control group that received no drugs and a Ticlopidine-treated group (100mg/kg orally 3 hours before surgery). The vessels were prepared for scanning electron microscopy and were evaluated based on the platelet aggregates at the endarterectomized site. The Mann-Whitney U test identified a statistically significant difference between the control group and the drug-treated group (U=82.50, p< 0.05). This study proves that Ticlopidine has a preventive effect on platelet aggregation in endarterectomized carotid arteries and that it can be used to reduce postoperative thrombus formation after carotid endarterectomy. | URI: | https://hdl.handle.net/11499/5611 | ISSN: | 1019-5149 |
| Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu |
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