Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/56254
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dc.contributor.authorÜnver Koluman, Başak-
dc.contributor.authorÇil, Nazlı-
dc.contributor.authorMete, Gülçin Abban-
dc.date.accessioned2024-01-21T19:50:23Z-
dc.date.available2024-01-21T19:50:23Z-
dc.date.issued2023-
dc.identifier.issn0019-5189-
dc.identifier.issn0975-1009-
dc.identifier.urihttps://doi.org/10.56042/ijeb.v61i11.1764-
dc.identifier.urihttps://hdl.handle.net/11499/56254-
dc.description.abstractCyclophosphamide (CTX) is an effective chemotherapeutic agent. Gonadotropins are molecules with various actions. Here, we investigated the effects of gonadotropins on the peripheral blood, bone marrow and spleen in rats administered with CTX. Three groups were formed: Control (C) group with no process; Sham (S) group: Physiological saline was applied; CTX group: A single dose of 200 mg/kg and 8 mg/kg CTX was administered for the next 14 days. All rats were superovulated with 150-300 IU/kg pregnant mare serum gonadotropin. Human chorionic gonadotropin @150-300 IU/kg was given, and complete blood counts, bone marrow smears, and spleen sections were examined; and also the expression of WNT-1, WNT-4, and 0-catenin was analyzed. Although the hemoglobin and platelet value in the CTX group was lowest, it was still within the normal reference ranges. The C and S groups had significantly higher white blood cell values (p=0.017). In terms of number of megakaryocytes, Myeloid/ Erythroid ratio, lymphoid cell ratios, no significant differences were found in bone marrow aspiration smears. The CTX group had significantly higher 0-catenin expression in the red pulp than the other groups (p=0.0001). The CTX group had the highest WNT-4 expression and very intense expression of WNT-1 in the white pulp. Our results indicate that the gonadotropins, promising in treatment, have favourable effects on toxicity of CTX.en_US
dc.language.isoenen_US
dc.publisherNatl Inst Science Communication-Niscairen_US
dc.relation.ispartofIndian Journal of Experimental Biologyen_US
dc.rightsinfo:eu-repo/semantics/openAccessen_US
dc.subjectCytotoxic chemotherapyen_US
dc.subjectDrug toxicityen_US
dc.subjectHuman Chorionic-Gonadotropinen_US
dc.subjectHormoneen_US
dc.subjectPathwayen_US
dc.subjectMiceen_US
dc.titleEffect of gonadotropins on blood, bone marrow and spleen in cyclophosphamide exposed ratsen_US
dc.typeArticleen_US
dc.identifier.volume61en_US
dc.identifier.issue11en_US
dc.identifier.startpage861en_US
dc.identifier.endpage870en_US
dc.departmentPamukkale Universityen_US
dc.identifier.doi10.56042/ijeb.v61i11.1764-
dc.relation.publicationcategoryMakale - Uluslararası Hakemli Dergi - Kurum Öğretim Elemanıen_US
dc.identifier.wosWOS:001115798500008en_US
dc.institutionauthor-
item.languageiso639-1en-
item.fulltextWith Fulltext-
item.openairetypeArticle-
item.openairecristypehttp://purl.org/coar/resource_type/c_18cf-
item.cerifentitytypePublications-
item.grantfulltextopen-
crisitem.author.dept14.02. Internal Medicine-
crisitem.author.dept14.03. Basic Medical Sciences-
crisitem.author.dept14.03. Basic Medical Sciences-
Appears in Collections:Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection
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