Please use this identifier to cite or link to this item:
https://hdl.handle.net/11499/56265
Title: | Investigation of the relationship between interferon-gamma receptor 1-56C/ T gene polymorphism and genetic susceptibility to lung sarcoidosis: A cross-sectional study [2] | Authors: | Kaymaz, Serdar Kavas, Murat Demiray, Aydın Karasu, Uğur Çobankara, Veli Boğa, Sibel |
Keywords: | Interferon-gamma receptor 1 sarcoidosis polymorphism. Pulmonary Sarcoidosis Th17 Cells Ifn-Gamma Risk Association Infection Cytokines Promoter Lymphocytes Therapy |
Publisher: | Turkish League Against Rheumatism | Abstract: | Objectives: This study aims to investigate the relationship between the interferon-gamma receptor 1 (IFNGR1) polymorphism and susceptibility to lung sarcoidosis. Patients and methods: The study included a total of 55 patients (13 males, 42 females; mean age: 46.5 +/- 9.1 years; range, 22 to 66 years) with lung sarcoidosis and 28 healthy controls (6 males, 22 females; mean age: 43.9 +/- 5.9 years; range 22 to 60 years) selected from the Turkish population. The polymerase chain reaction was used for genotyping of participants to determine single-nucleotide polymorphisms. Hardy- Weinberg equilibrium, which is considered an important tool for detecting genotyping errors, was tested. Allele and genotype frequencies of patients and controls were compared using logistic regression analysis. Results: The analyses showed no correlation between the tested IFNGR1 single-nucleotide polymorphism (rs2234711) and lung sarcoidosis (p>0.05). The categorization analysis according to the clinical features, laboratory, and radiographic characteristics showed no correlation between the tested polymorphism of IFNGR1 (rs2234711) and these characteristics (p>0.05). Conclusion: The results of the study showed that the tested gene polymorphism (rs2234711) of IFNGR1 was not associated with lung sarcoidosis. More comprehensive studies are needed to verify our results. | URI: | https://doi.org/10.46497/ArchRheumatol.2022.9239 https://hdl.handle.net/11499/56265 |
ISSN: | 2618-6500 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
Show full item record
CORE Recommender
WEB OF SCIENCETM
Citations
1
checked on Aug 9, 2024
Page view(s)
50
checked on Aug 24, 2024
Google ScholarTM
Check
Altmetric
Items in GCRIS Repository are protected by copyright, with all rights reserved, unless otherwise indicated.