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https://hdl.handle.net/11499/56265
Title: | Investigation of the relationship between interferon-gamma receptor 1-56C/ T gene polymorphism and genetic susceptibility to lung sarcoidosis: A cross-sectional study [2] | Authors: | Kaymaz, Serdar Kavas, Murat Demiray, Aydın Karasu, Uğur Çobankara, Veli Boğa, Sibel |
Keywords: | Interferon-gamma receptor 1 sarcoidosis polymorphism. Pulmonary Sarcoidosis Th17 Cells Ifn-Gamma Risk Association Infection Cytokines Promoter Lymphocytes Therapy |
Publisher: | Turkish League Against Rheumatism | Abstract: | Objectives: This study aims to investigate the relationship between the interferon-gamma receptor 1 (IFNGR1) polymorphism and susceptibility to lung sarcoidosis. Patients and methods: The study included a total of 55 patients (13 males, 42 females; mean age: 46.5 +/- 9.1 years; range, 22 to 66 years) with lung sarcoidosis and 28 healthy controls (6 males, 22 females; mean age: 43.9 +/- 5.9 years; range 22 to 60 years) selected from the Turkish population. The polymerase chain reaction was used for genotyping of participants to determine single-nucleotide polymorphisms. Hardy- Weinberg equilibrium, which is considered an important tool for detecting genotyping errors, was tested. Allele and genotype frequencies of patients and controls were compared using logistic regression analysis. Results: The analyses showed no correlation between the tested IFNGR1 single-nucleotide polymorphism (rs2234711) and lung sarcoidosis (p>0.05). The categorization analysis according to the clinical features, laboratory, and radiographic characteristics showed no correlation between the tested polymorphism of IFNGR1 (rs2234711) and these characteristics (p>0.05). Conclusion: The results of the study showed that the tested gene polymorphism (rs2234711) of IFNGR1 was not associated with lung sarcoidosis. More comprehensive studies are needed to verify our results. | URI: | https://doi.org/10.46497/ArchRheumatol.2022.9239 https://hdl.handle.net/11499/56265 |
ISSN: | 2618-6500 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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