One-year follow-up of the oxidative stress profile of patients after laparoscopic sleeve gastrectomy

Abstract

- OBJECTIVE: Obesity is a ma-jor risk factor for developing a number of seri-ous diseases, such as cardiometabolic chang-es and cancer. An increase in adipose tissue and a decrease in antioxidant capacity both con-tribute to the etiopathogenesis of these comor-bidities. The most effective method in the treat-ment of morbid obesity is bariatric surgery. Lap-aroscopic sleeve gastrectomy (LSG) is the most preferred method in bariatric surgery today. In this study, the potential improvement effect of laparoscopic sleeve gastrectomy (LSG) surgery in the restoration of weight loss and endocrine and tissue-based deterioration was obtained by evaluating changes in oxidative stress, antioxi-dant agents, and lipid oxidation levels. PATIENTS AND METHODS: Fifty patients who had LSG surgery were chosen, along with 50 healthy volunteers who were the same age and gender as these patients. Serum total antiox-idant capacity measurement, total oxidant capac-ity measurement, malondialdehyde (MDA) for the measurement of lipid peroxidation degree, and superoxide dismutase (SOD) and glutathione per-oxidase (GPx) levels for the measurement of an-tioxidant levels were measured colorimetrically with the help of a commercial kit. RESULTS: Oxidative stress indices, MDA lev-els, and GPx levels of patients with morbid obe-sity treated with LSG were observed to decrease significantly compared to the preoperative peri- od, while no significant changes were observed in SOD levels. CONCLUSIONS: In patients with morbidly obese conditions, the weight control achieved by sleeve gastrectomy, which is a restrictive method and thus causes a decrease in adipose tissue, causes a decrease in oxidative stress and an increase in the antioxidant response.