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https://hdl.handle.net/11499/56558
Title: | Investigation of controlled drug release of ibuprofen with prepared and characterized innovative bigel materials | Other Titles: | Untersuchung der kontrollierten Wirkstofffreisetzung von Ibuprofen mit präparierten und charakterisierten innovativen Bigel-Materialien | Authors: | Kizilhan, E. Özcan, Y. Erden, Gönenmiş, D. Mutlu, D. Gök, C. Arslan, Ş. |
Keywords: | bigel controlled drug release hydrogel ibuprofen organogel Biocompatibility Differential scanning calorimetry Drug products Fourier transform infrared spectroscopy Hydrogels Kinetic theory Kinetics Swelling Targeted drug delivery Bigel Black cumin oil Controlled drug release Cytocompatibility Human keratinocyte Ibuprofen In-vitro Kinetic models Organogels Swelling test Controlled drug delivery |
Publisher: | John Wiley and Sons Inc | Abstract: | New systems called bigels have been discovered recently, alongside other consolidations of hydrogels and organogels. The purpose of this research is to develop bigels using span 40, alginate, centaury oil, black cumin oil and sorbitan monopalmitate for controlled ibuprofen release. Characterization of prepared materials was performed using various analysis by fourier transform infrared spectroscopy and differential scanning calorimetry. The pH 7.2 level was used for the swelling test of bigels. Cytocompatibility of bigels was determined by using human immortalized human keratinocyte cells. Bigels have been tested for their effectiveness as controlled medication delivery formulations by in vitro studies. The prepared bigels did not show any toxic effects on human cells. This indicates that the prepared materials were biocompatible. For controlled drug release kinetics, zeroth-order, first-order, Higuchi, and Korsmeyer-Peppas kinetic models were used. According to results, the kinetic modeling of bigels by Korsmeyer-Peppas is also highly compatible. Consequently, controlled drug release was successfully carried out by the novel bigel materials formed by adding an active ingredient. Our results clearly indicate that bigels have been an alternative potential material for controlled drug delivery systems by the properties of biocompatibility, slower release of the drug and the diffusion release mechanism. © 2023 Wiley-VCH GmbH. | URI: | https://doi.org/10.1002/mawe.202300045 https://hdl.handle.net/11499/56558 |
ISSN: | 0933-5137 |
Appears in Collections: | Fen Fakültesi Koleksiyonu Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Teknoloji Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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