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https://hdl.handle.net/11499/5825
Title: | Prognostic role of Tc-99m pertechnetate thyroid scintigraphy prior to fixed-dose radioiodine therapy of toxic multinodular goiters | Authors: | Yüksel, Doğangün Kıraç, Fatma Suna Yaylalı, Olga Demiray Uguz, I. |
Keywords: | I-131 Radioiodine Tc-99m pertechnetate Toxic multinodular goiter iodine 131 pertechnetic acid tc 99m propylthiouracil adult aged article clinical article clinical assessment controlled study drug tumor level echography euthyroidism female human hypothyroidism image analysis male outcome assessment prognosis retrospective study salivary gland thyroid nodule thyroid scintiscanning toxic goiter treatment response |
Abstract: | Aim: To investigate the prognostic role of Tc-99m pertechnetate thyroid scintigraphy pretreatment in patients with toxic multinodular goiters (TMNG) who were then treated with fixed I-131 doses. Materials and methods: We retrospectively evaluated 28 patients (18 females and 10 males; mean ± SD = 63 ± 11 years) that were treated with 740 megabecquerels (MBq) of I-131 for TMNG. Information, including age, Tc-99m pertechnetate thyroid scintigraphy and ultrasonography findings, antithyroid medication, thyroid hormone profile, and clinical status before treatment, was recorded. Th e regions of interest were drawn over the hot nodules, salivary glands, and the background on the anterior thyroid images. Th e net nodule counts, net salivary counts, nodule-to-salivary ratios, and nodule-to-background ratios were then calculated. The data were statistically compared for the hypothyroid and euthyroid patient groups after radioiodine treatment. Results: In the study group, the mean follow-up period was 7 ± 2 months (range: 6-12 months). We detected hyperthyroidism in 1 patient, euthyroidism in 19 patients, and hypothyroidism in 8 patients. Th e pretreatment mean net nodule counts (34.79 ± 14.06 counts) in the patients that developed hypothyroidism were significantly higher than in those patients that developed euthyroidism (26.80 ± 11.04 counts) (P = 0.014). The other 3 parameters did not show significant differences between the 2 groups. Conclusion: Th e Tc-99m pertechnetate uptake level of hot nodules calculated from the pretreatment of thyroid scintigraphy in patients with TMNG treated with a fixed 740-MBq I-131 dose may predict early hypothyroidism in patients. © TÜBİTAK. | URI: | https://hdl.handle.net/11499/5825 https://doi.org/10.3906/sag-1010-1232 |
ISSN: | 1300-0144 |
Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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