Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5825
Title: Prognostic role of Tc-99m pertechnetate thyroid scintigraphy prior to fixed-dose radioiodine therapy of toxic multinodular goiters
Authors: Yüksel, Doğangün
Kıraç, Fatma Suna
Yaylalı, Olga
Demiray Uguz, I.
Keywords: I-131
Radioiodine
Tc-99m pertechnetate
Toxic multinodular goiter
iodine 131
pertechnetic acid tc 99m
propylthiouracil
adult
aged
article
clinical article
clinical assessment
controlled study
drug tumor level
echography
euthyroidism
female
human
hypothyroidism
image analysis
male
outcome assessment
prognosis
retrospective study
salivary gland
thyroid nodule
thyroid scintiscanning
toxic goiter
treatment response
Abstract: Aim: To investigate the prognostic role of Tc-99m pertechnetate thyroid scintigraphy pretreatment in patients with toxic multinodular goiters (TMNG) who were then treated with fixed I-131 doses. Materials and methods: We retrospectively evaluated 28 patients (18 females and 10 males; mean ± SD = 63 ± 11 years) that were treated with 740 megabecquerels (MBq) of I-131 for TMNG. Information, including age, Tc-99m pertechnetate thyroid scintigraphy and ultrasonography findings, antithyroid medication, thyroid hormone profile, and clinical status before treatment, was recorded. Th e regions of interest were drawn over the hot nodules, salivary glands, and the background on the anterior thyroid images. Th e net nodule counts, net salivary counts, nodule-to-salivary ratios, and nodule-to-background ratios were then calculated. The data were statistically compared for the hypothyroid and euthyroid patient groups after radioiodine treatment. Results: In the study group, the mean follow-up period was 7 ± 2 months (range: 6-12 months). We detected hyperthyroidism in 1 patient, euthyroidism in 19 patients, and hypothyroidism in 8 patients. Th e pretreatment mean net nodule counts (34.79 ± 14.06 counts) in the patients that developed hypothyroidism were significantly higher than in those patients that developed euthyroidism (26.80 ± 11.04 counts) (P = 0.014). The other 3 parameters did not show significant differences between the 2 groups. Conclusion: Th e Tc-99m pertechnetate uptake level of hot nodules calculated from the pretreatment of thyroid scintigraphy in patients with TMNG treated with a fixed 740-MBq I-131 dose may predict early hypothyroidism in patients. © TÜBİTAK.
URI: https://hdl.handle.net/11499/5825
https://doi.org/10.3906/sag-1010-1232
ISSN: 1300-0144
Appears in Collections:Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
TR Dizin İndeksli Yayınlar Koleksiyonu / TR Dizin Indexed Publications Collection
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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