Celiac disease and gut microbiota: Herbal treatment and gluten-free diet

Abstract

Celiac disease (CD) manifests as a targeted autoimmune response that adversely affects the small intestine, primarily affecting individuals with a particular genetic predisposition. Diagnosis centers on identifying this gluten-sensitive enteropathy, which can be ameliorated through the implementation of a gluten-free diet (GFD), correlating with mucosal healing and symptom alleviation. The human microbiota, a vast symbiotic community within the gastrointestinal tract, profoundly impacts human health. Advances in genome sequencing have elucidated the intricate relationship between gut microbiota and autoimmune diseases, including CD, emphasizing the significant role of dietary patterns in shaping the gut microbiota. The influence of GFD on microbiota composition, the only clinically validated treatment for CD, leads to a nutritional shift and potential macronutrient imbalance. Emerging research also highlights the therapeutic potential of various herbs with antioxidant, anti-inflammatory, antimicrobial, gastroprotective, and immunomodulatory properties as complementary approaches to manage CD. This chapter synthesizes the complex interactions between genetics, diet, gut microbiota, and potential herbal interventions in CD, paving the way for more comprehensive understanding and management strategies. © 2024 Bentham Science Publishers.