Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/5916
Title: Quercetin-induced apoptosis involves increased hTERT enzyme activity of leukemic cells
Authors: Avci, C.B.
Yilmaz, S.
Dogan, Z.O.
Saydam, G.
Dodurga, Yavuz
Ekiz, H.A.
Kartal, M.
Keywords: Apoptosis
hTERT
Leukemia
Quercetin
Telomerase
acridine orange
ethidium bromide
quercetin
telomerase reverse transcriptase
trypan blue
acute lymphoblastic leukemia
antineoplastic activity
apoptosis
article
cancer inhibition
cell proliferation
cell viability
chronic myeloid leukemia
concentration response
controlled study
drug cytotoxicity
drug effect
enzyme activity
enzyme assay
enzyme repression
fluorescence microscopy
human
human cell
leukemia cell
lymphatic leukemia
priority journal
promyelocytic leukemia
Antineoplastic Agents
Antioxidants
Cell Line, Tumor
Cell Survival
Dose-Response Relationship, Drug
Enzyme Activation
Gene Expression Regulation, Leukemic
HL-60 Cells
Humans
K562 Cells
RNA, Messenger
Abstract: We aimed to examine the growth suppressive effects of quercetin on acute promyelocytic and lymphoblastic leukemia and chronic myeloid leukemia, and to find out whether the growth suppression is related to the blocking of telomerase enzyme activity. Cytotoxic effects of quercetin were shown by trypan blue analyses. Apoptotic effects of quercetin were examined by acridine orange and ethidium bromide staining by fluorescence microscopy. The effects of quercetin on telomerase enzyme activity were shown by hTERT Quantification Kit. Our results demonstrated that quercetin has antiproliferative and apoptotic effects on T-cell acute lymphoblastic leukemia (ALL), acute promyelocytic leukemia, and chronic myeloid leukemia (CML) cells. We also showed for the first time by this study that quercetin suppresses the activity of telomerase in ALL and CML cells. The results of this study show the importance of quercetin for its therapeutic potential in treatment of leukemias. © W. S. Maney & Son Ltd 2011.
URI: https://hdl.handle.net/11499/5916
https://doi.org/10.1179/102453311X13085644680104
ISSN: 1024-5332
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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