Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/6051
Title: Is the dopamine D3 receptor mRNA on blood lymphocytes help to for identification and subtyping of schizophrenia?
Authors: Urhan-Kucuk, M.
Erdal, M.E.
Ozen, M.E.
Kul, S.
Herken, Hasan
Keywords: DRD3 mRNA
PBL
RT-PCR
Schizophrenia
dopamine 3 receptor
messenger RNA
diagnostic agent
primer DNA
adult
article
controlled study
disease marker
disease severity
female
human
human cell
lymphocyte
major clinical study
male
reverse transcription polymerase chain reaction
RNA analysis
RNA isolation
schizophrenia
classification
genetics
metabolism
nonparametric test
DNA Primers
Humans
Lymphocytes
Receptors, Dopamine D3
Reverse Transcriptase Polymerase Chain Reaction
RNA, Messenger
Statistics, Nonparametric
Abstract: Schizophrenia is one of the neuropathological disorders, which are associated with dopamine and its receptors. In recent years, it has been shown that mRNA of D3, D4 and D5 dopamine receptor (DRD3, DRD4, DRD5) subtypes is expressed in human peripheral blood lymphocytes (PBL). A total 55 schizophrenic patients and 51 healthy subjects were included in the study to investigate the levels of DRD3 mRNA in PBL of schizophrenic patients and whether DRD3 mRNA level in PBL can serve as peripheral marker for schizophrenia. RNA was isolated from lymphocytes of both groups and reverse transcriptase polymerase chain reaction (RT-PCR) was performed for DRD3 mRNA. We found a significant difference in PBL DRD3 mRNA levels among schizophrenia subtypes (P = 0.030) while no difference was detected between control subjects and schizophrenics. We concluded that the levels of DRD3 mRNA can help understanding and severity of clinical manifestations in schizophrenia. © Springer Science+Business Media B.V. 2010.
URI: https://hdl.handle.net/11499/6051
https://doi.org/10.1007/s11033-010-0396-4
ISSN: 0301-4851
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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