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https://hdl.handle.net/11499/7067| Title: | HBV X protein: Elucidating a role in oncogenesis | Authors: | Feitelson, M.A. Reis, H.M.G.P.V. Pan, J. Clayton, M. Sun, B. Satiroglu-Tufan, N.L. Lian, Z. |
Keywords: | Apoptosis Fibrosis Hepatitis B x antigen Hepatocellular carcinoma Senescence Signal transduction Steatosis Treatment Tumor suppressors hepatitis B virus X protein immunoglobulin enhancer binding protein mitogen activated protein kinase peroxisome proliferator activated receptor gamma phosphatidylinositol 3 kinase phosphatidylinositol 3,4,5 trisphosphate 3 phosphatase protein kinase B protein p53 Raf protein Ras protein sorafenib sterol regulatory element binding protein 1 transforming growth factor beta1 tumor necrosis factor alpha Wnt protein apoptosis cancer inhibition chronic liver disease down regulation enzyme inhibition fibrogenesis gene expression regulation hepatitis hepatitis B Hepatitis B virus human liver carcinogenesis liver cell carcinoma nonhuman oxidative stress priority journal review upregulation virus replication Animalia |
Abstract: | Chronic HBV infection is associated with the development of hepatocellular carcinoma (HCC). HBV contributes to tumorigenesis by encoding hepatitis B x antigen (HBxAg), which is a trans-regulatory protein that appears to contribute to HCC by altering patterns of host gene expression. In this review, recent data is presented that outlines some of the putative mechanisms whereby HBxA9 contributes to HCC. With the development of animal models of HBxAg-mediated HCC, the relevance and temporal order of putative steps in this process can now be dissected to elucidate what is rate limiting and when. This will have a profound impact on the design of novel and specific therapeutics for HCC. © 2008 Future Medicine Ltd. | URI: | https://hdl.handle.net/11499/7067 https://doi.org/10.2217/17460794.3.5.455 |
ISSN: | 1746-0794 |
| Appears in Collections: | Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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