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https://hdl.handle.net/11499/7098
Title: | Efficacy of linezolid in the treatment of mediastinitis due to methicillin-resistant Staphylococcus aureus: an experimental study | Authors: | Saçar, Mustafa Saçar, Suzan Kaleli, İlknur Cevahir, Nural Teke, Zafer Kavas, Semra Toprak Asan, Ali |
Keywords: | Linezolid Surgical site infection linezolid rifampicin animal experiment animal model animal tissue antibiotic therapy article bacterial count bacterium culture combination chemotherapy controlled study drug efficacy drug megadose drug potentiation experimental study human male mediastinitis methicillin resistant Staphylococcus aureus monotherapy nonhuman postoperative infection quantitative analysis rat sternotomy sternum treatment outcome Acetamides Animals Anti-Bacterial Agents Disease Models, Animal Dose-Response Relationship, Drug Drug Therapy, Combination Male Mediastinitis Methicillin Resistance Oxazolidinones Rats Rifampin Staphylococcal Infections Staphylococcus aureus Surgical Wound Infection |
Abstract: | Introduction: The treatment of postoperative mediastinitis is very important because of its high morbidity, mortality, and increased hospital stay and hospital costs. The aims of our research were to investigate whether linezolid alone can be an effective treatment agent for methicillin-resistant Staphylococcus aureus (MRSA) mediastinitis, and to determine whether linezolid can provide synergistic activity when given in combination with rifampin. Methods: A partial upper median sternotomy was performed on 70 rats. The animals were divided into seven groups: an uncontaminated control group; an untreated contaminated group; three contaminated groups that received antibiotic therapy with either 25 or 50 mg/kg linezolid twice a day, or rifampin 5 mg/kg twice a day; and two contaminated groups that received a combination therapy consisting of 25 or 50 mg/kg linezolid and rifampin 5 mg/kg twice a day. The antibiotic treatment lasted 7 days. Tissue samples from the upper ends of the sternum and swab specimens of the upper mediastinum were obtained and evaluated microbiologically. Results: The 25-mg/kg dose of linezolid, either alone or combined with rifampin, was not effective in reducing the bacterial counts in mediastinum and sternum. Quantitative bacterial cultures of mediastinum and sternum were significantly lower in the groups receiving 50 mg/kg linezolid alone or in combination with rifampin compared with the control. Adding of rifampin to linezolid therapy did not result in a significant change in bacterial counts versus linezolid alone. Conclusion: A high dose of linezolid should be considered as a possible therapeutic agent for the treatment of post-sternotomy infection caused by MRSA. © 2007 International Society for Infectious Diseases. | URI: | https://hdl.handle.net/11499/7098 https://doi.org/10.1016/j.ijid.2007.09.017 |
ISSN: | 1201-9712 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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