Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7098
Title: Efficacy of linezolid in the treatment of mediastinitis due to methicillin-resistant Staphylococcus aureus: an experimental study
Authors: Saçar, Mustafa
Saçar, Suzan
Kaleli, İlknur
Cevahir, Nural
Teke, Zafer
Kavas, Semra Toprak
Asan, Ali
Keywords: Linezolid
Surgical site infection
linezolid
rifampicin
animal experiment
animal model
animal tissue
antibiotic therapy
article
bacterial count
bacterium culture
combination chemotherapy
controlled study
drug efficacy
drug megadose
drug potentiation
experimental study
human
male
mediastinitis
methicillin resistant Staphylococcus aureus
monotherapy
nonhuman
postoperative infection
quantitative analysis
rat
sternotomy
sternum
treatment outcome
Acetamides
Animals
Anti-Bacterial Agents
Disease Models, Animal
Dose-Response Relationship, Drug
Drug Therapy, Combination
Male
Mediastinitis
Methicillin Resistance
Oxazolidinones
Rats
Rifampin
Staphylococcal Infections
Staphylococcus aureus
Surgical Wound Infection
Abstract: Introduction: The treatment of postoperative mediastinitis is very important because of its high morbidity, mortality, and increased hospital stay and hospital costs. The aims of our research were to investigate whether linezolid alone can be an effective treatment agent for methicillin-resistant Staphylococcus aureus (MRSA) mediastinitis, and to determine whether linezolid can provide synergistic activity when given in combination with rifampin. Methods: A partial upper median sternotomy was performed on 70 rats. The animals were divided into seven groups: an uncontaminated control group; an untreated contaminated group; three contaminated groups that received antibiotic therapy with either 25 or 50 mg/kg linezolid twice a day, or rifampin 5 mg/kg twice a day; and two contaminated groups that received a combination therapy consisting of 25 or 50 mg/kg linezolid and rifampin 5 mg/kg twice a day. The antibiotic treatment lasted 7 days. Tissue samples from the upper ends of the sternum and swab specimens of the upper mediastinum were obtained and evaluated microbiologically. Results: The 25-mg/kg dose of linezolid, either alone or combined with rifampin, was not effective in reducing the bacterial counts in mediastinum and sternum. Quantitative bacterial cultures of mediastinum and sternum were significantly lower in the groups receiving 50 mg/kg linezolid alone or in combination with rifampin compared with the control. Adding of rifampin to linezolid therapy did not result in a significant change in bacterial counts versus linezolid alone. Conclusion: A high dose of linezolid should be considered as a possible therapeutic agent for the treatment of post-sternotomy infection caused by MRSA. © 2007 International Society for Infectious Diseases.
URI: https://hdl.handle.net/11499/7098
https://doi.org/10.1016/j.ijid.2007.09.017
ISSN: 1201-9712
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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