Please use this identifier to cite or link to this item: https://hdl.handle.net/11499/7187
Title: Changes in regional cerebral blood flow demonstrated by 99mTc-HMPAO SPECT in euthymic bipolar patients
Authors: Çulha, Ateşçi Figen
Özdel, Osman İsmail
Doğangün, Yüksel
Filiz, Karadağ
Suna, Kıraç
Kalkan, Oğuzhanoğlu Nalan
Gülfizar, Varma
Keywords: Brain imaging
Cerebral perfusion
Cingulate gyrus
Euthymic bipolar disorder
hexamethylpropylene amine oxime technetium tc 99m
lithium
olanzapine
risperidone
valproic acid
adult
article
bipolar disorder
brain blood flow
brain dysfunction
brain perfusion
brain region
cingulate gyrus
clinical article
controlled study
depression
diagnostic and statistical manual of mental disorders
female
frontal lobe
human
male
mania
occipital lobe
parietal lobe
priority journal
single photon emission computer tomography
temporal lobe
Adult
Affect
Bipolar Disorder
Brain
Brain Mapping
Case-Control Studies
Cerebrovascular Circulation
Female
Humans
Male
Radiopharmaceuticals
Reference Values
Technetium Tc 99m Exametazime
Tomography, Emission-Computed, Single-Photon
Abstract: Single photon emission computed tomography (SPECT) with 99mTc-HMPAO was used to compare regional cerebral blood flow (rCBF) in patients with bipolar disorder and in healthy controls. The sample of this study consisted of 16 euthymic bipolar patients who met the DSM-IV criteria and 10 healthy control subjects. The mean regional cerebral blood flow values of the bipolar euthymic patients were significantly lower than those of the controls in the bilateral medial-basal temporal, occipital; medial frontal; parietal regions and in the cingulate gyrus; the hypoperfusion in the cingulate had the highest significant P value (.001, Bonferroni correction). No significant differences in rCBF emerged between right and left-brain regions. The most important findings of the current study are the presence of regional cerebral perfusion alterations, particularly in the cingulate gyrus in the euthymic bipolar patients. Our results imply that underlying brain dysfunction may be independent from manic or depressive episodes in bipolar disorder. Because of the small number of subjects, however, this finding should be viewed as preliminary. © 2007 Springer.
URI: https://hdl.handle.net/11499/7187
https://doi.org/10.1007/s00406-007-0766-7
ISSN: 0940-1334
Appears in Collections:PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection
Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection
Tıp Fakültesi Koleksiyonu
WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection

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