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https://hdl.handle.net/11499/7187
Title: | Changes in regional cerebral blood flow demonstrated by 99mTc-HMPAO SPECT in euthymic bipolar patients | Authors: | Çulha, Ateşçi Figen Özdel, Osman İsmail Doğangün, Yüksel Filiz, Karadağ Suna, Kıraç Kalkan, Oğuzhanoğlu Nalan Gülfizar, Varma |
Keywords: | Brain imaging Cerebral perfusion Cingulate gyrus Euthymic bipolar disorder hexamethylpropylene amine oxime technetium tc 99m lithium olanzapine risperidone valproic acid adult article bipolar disorder brain blood flow brain dysfunction brain perfusion brain region cingulate gyrus clinical article controlled study depression diagnostic and statistical manual of mental disorders female frontal lobe human male mania occipital lobe parietal lobe priority journal single photon emission computer tomography temporal lobe Adult Affect Bipolar Disorder Brain Brain Mapping Case-Control Studies Cerebrovascular Circulation Female Humans Male Radiopharmaceuticals Reference Values Technetium Tc 99m Exametazime Tomography, Emission-Computed, Single-Photon |
Abstract: | Single photon emission computed tomography (SPECT) with 99mTc-HMPAO was used to compare regional cerebral blood flow (rCBF) in patients with bipolar disorder and in healthy controls. The sample of this study consisted of 16 euthymic bipolar patients who met the DSM-IV criteria and 10 healthy control subjects. The mean regional cerebral blood flow values of the bipolar euthymic patients were significantly lower than those of the controls in the bilateral medial-basal temporal, occipital; medial frontal; parietal regions and in the cingulate gyrus; the hypoperfusion in the cingulate had the highest significant P value (.001, Bonferroni correction). No significant differences in rCBF emerged between right and left-brain regions. The most important findings of the current study are the presence of regional cerebral perfusion alterations, particularly in the cingulate gyrus in the euthymic bipolar patients. Our results imply that underlying brain dysfunction may be independent from manic or depressive episodes in bipolar disorder. Because of the small number of subjects, however, this finding should be viewed as preliminary. © 2007 Springer. | URI: | https://hdl.handle.net/11499/7187 https://doi.org/10.1007/s00406-007-0766-7 |
ISSN: | 0940-1334 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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