A case of SAPHO syndrome presenting with positive HLA-B27 and multiple bone involvement: Case report

Abstract

The SAPHO syndrome (synovitis, acne, pustulosis, hyperostosis and osteitis) is a rare syndrome with precise bone lesions and dermatologic manifestations. We report an unusual case of SAPHO syndrome with joint involvement preceding the appearance of psoriasis by years. Another unusual feature noted in our case was the multiple involvement of bone and joints. These patients can successfully be treated with steroids and methotrexate with a long-term remission. We present our case in the light of evidence obtained by an extensive review of the literature, to support the view that SAPHO may not be rare at all, but may easily be confused with seronegative spondyloarthropathy and/or psoriatic: arthritis. Copyright © 2008 by Türkiye Klinikleri.