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https://hdl.handle.net/11499/7331
Title: | Evaluation of whether the ACE gene I/D polymorphism constitutes a risk factor for chronic obstructive pulmonary disease in the Turkish population | Authors: | Ayada, C. Toru, Ü. Genç, O. Yerlikaya, A. Şahin, S. Turgut, Sebahat Turgut, Günfer |
Keywords: | Angiotensin converting enzyme Chronic obstructive pulmonary disease Renin angiotensin system Turkish population dipeptidyl carboxypeptidase genomic DNA ACE protein, human ACE gene allele Article blood sampling chronic obstructive lung disease clinical article controlled study DNA determination DNA isolation gene expression gene frequency gene function gene identification genetic polymorphism genetic risk genetic variability genotype geographic distribution heterozygosity homozygosity human indel mutation pathophysiology polymerase chain reaction population genetics risk factor Turk (people) Turkey (republic) genetic association genetic predisposition genetics pathology renin angiotensin aldosterone system Turkey Gene Frequency Genetic Association Studies Genetic Predisposition to Disease Humans INDEL Mutation Peptidyl-Dipeptidase A Pulmonary Disease, Chronic Obstructive Renin-Angiotensin System Risk Factors |
Publisher: | Fundacao de Pesquisas Cientificas de Ribeirao Preto | Abstract: | Chronic obstructive pulmonary disease (COPD) is characterized by progressive airflow obstruction that occurs as a result of the normal inflammatory process to protect against harmful irritants and chemicals. Another physiological regulatory process, the renin angiotensin system (RAS), plays an important role in the pathology of many diseases. Angiotensin converting enzyme (ACE) is a key enzyme of RAS. We investigated the frequency of the ACE gene I/D polymorphism in patients with COPD in Turkey. This study was performed on 47 unrelated patients with COPD and 64 healthy subjects. DNA samples were isolated from peripheral blood, and ACE DNA was amplified by polymerase chain reaction. The frequencies of ACE genotypes were 27.7, 55.3, and 17% for DD, ID, and II in the COPD group, respectively, and 43.8, 43.8, and 12.4% in the control group. There was no statistically significant difference between groups (?2 = 3.078; df = 2; P = 0.220). The distributions of ACE gene D alleles were 38.2% (N = 52) in the COPD group and 61.8% (N = 84) in the control group; and those of I alleles were 48.8% (N = 42) in the COPD group and 51.2% (N = 44) in the control group. There was no statistically significant difference between groups for allele frequency (?2 = 2.419; df = 2; P = 0.120). We believe these results can be useful for large-scale population genetic research considering the frequency of the ACE gene variation in COPD patients in the Turkish population. © FUNPEC-RP. | URI: | https://hdl.handle.net/11499/7331 https://doi.org/10.4238/2014.December.12.4 |
ISSN: | 1676-5680 |
Appears in Collections: | PubMed İndeksli Yayınlar Koleksiyonu / PubMed Indexed Publications Collection Scopus İndeksli Yayınlar Koleksiyonu / Scopus Indexed Publications Collection Tıp Fakültesi Koleksiyonu WoS İndeksli Yayınlar Koleksiyonu / WoS Indexed Publications Collection |
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